ArticleJournal of diabetes and metabolic disorders2025
Highlighted gene expression alteration in human pancreatic isolated islets in patients with type 2 diabetes.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Type 2 diabetes is a complex disease characterized by progressive β-cell failure. The primary mechanism underlying this failure is the progressive loss of pancreatic β-cell function. The aim of this study is to identify the key gene expression changes in human pancreatic isolated islets of patients with type 2 diabetes. Methods: We extracted gene expression data in human pancreatic isolated islets of patients with type 2 diabetes and healthy controls from Gene Expression Omnibus (GEO) and analyzed it using GEO2R program. We then assessed the significant differentially expressed genes (DEGs) using protein-protein interaction (PPI) network analysis. The critical genes were enriched via gene ontology and discussed. Results: Among the 93 significant DEGs, five critical genes including ITGB2, APOE, BIRC5, GABRA2, and IL1B were emerged as key players in type 2 diabetes. Notably, "Alzheimer disease, type 4" was identified as a major class of biological terms altered in type 2 diabetes. Conclusions: Our findings suggest that the introduced critical genes are potential targets for controlling type 2 diabetes. Furthermore, the crucial role of APOE as a link between type 2 diabetes and Alzheimer's disease or other cognitive disorders was confirmed.
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