ArticleBio-protocol2025
The Mouse Social Frailty Index (mSFI): A Standardized Protocol.
Article in Bio-protocol, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- How human and animal frailty index studies can inform each other: a brief narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Revisiting the social frailty index in aging adults: relevance and implications for an emerging construct.GeroScience · 2026Article
- Social and clinical frailty indices in aging mice: a comparative analysis of longitudinal and cross-sectional designs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
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Authors and funding
3 authors.
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Abstract
The advent of geroscience engendered the development of approaches to quantify the aging process and estimate biological age on an individual level. Recognizing that declines observed in aging are not only physical but also social led us to develop a mouse Social Frailty Index (mSFI) designed to quantify age-related impairments of social functioning in mice. The mSFI consists of seven behavioral assays that measure essential facets of social behavioral functioning in mice: social communication, social interaction, and social functional ability. The assays that comprise the mSFI are all minimally disruptive, relatively simple to execute, and optimized for compatibility with longitudinal studies utilizing experimental interventions relevant to geroscience. The mSFI is conducted over AM and PM sessions spanning a maximum of 3.5 days, using materials common to most animal facilities. The data for all assays is obtained observationally, manually recorded, and entered into predefined template sheets that automate the computation of the mSFI. We have demonstrated the validity and applicability of the mSFI across multiple laboratory sites and experiments. This index has proven to discriminate between differential trajectories of biological aging driven by sex, progeria, or social stress-relevant contexts. The mSFI represents a novel index to quantify trajectories of biological aging in mice, and its application may help elucidate the social dimensions of the aging process. Key features • The mSFI is a comprehensive assessment for the evaluation of impairment in social behavioral functioning related to aging in mice. • Minimally disruptive, relatively simple, commonly used high-throughput assays of spontaneous social behavior that are optimized for compatibility with longitudinal studies of aging. • The protocol spans AM and PM sessions over 3.5 days maximum; the sequence of individual assays is flexible by design. • The mSFI requires materials common to most animal research facilities. • mSFI application is compatible with most experimental treatments, social behavioral paradigms, longitudinal within-subject designs, and genetically modified mouse models.
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Registered trials
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