ReviewPain reports2025
Fibromyalgia: are you a genetic/environmental disease?
Review in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Controllable Pulse Parameter Transcranial Magnetic Stimulation in Fibromyalgia: A Randomized Control Study.Journal of pain research · 2026Article
- Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization.Frontiers in immunology · 2026Review
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia, characterized by chronic widespread pain and fatigue, involves complex interactions between genetic predispositions and environmental triggers. This review delves into the multifaceted nature of fibromyalgia, emphasizing recent advances in understanding its pathogenesis through genetic, epigenetic, and environmental lenses. We explore the roles of specific genetic polymorphisms, such as those in the catechol-O-methyltransferase and serotonin transporter genes, and their correlation with the syndrome's susceptibility. The review also examines the significant impact of environmental factors, including physical trauma and stress, which potentiate the syndrome's severity. In addition, emerging research on the microbiome and epigenetic modifications provides new insights into the disease mechanisms, potentially guiding future therapeutic strategies. This article aims to synthesize current research findings and propose directions for future research, underscoring the necessity of a multidisciplinary approach to decipher the complexities of fibromyalgia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.