Evidence map›Paper›PMID 40291377›Full record

ArticleMolecular therapy. Nucleic acids2025

Inhibition of the LINE1-derived

Umberto Miglio, Enrico Berrino, Daniele Avanzato, Ivan Molineris, Valentina Miano, Melissa Milan, Letizia Lanzetti, Eugenio Morelli, James M Hughes, Michele De Bortoli and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Umberto MiglioCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Enrico BerrinoCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Daniele AvanzatoDepartment of Oncology, University of Torino Medical School, 10043 Orbassano, TO, Italy.
Ivan MolinerisDepartment of Life Sciences and System Biology and MBC, University of Torino, 10123 Torino, Italy.
Valentina MianoDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, TO, Italy.
Melissa MilanCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Letizia LanzettiCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Eugenio MorelliCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
James M HughesCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Michele De BortoliDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, TO, Italy.
Anna SapinoCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.
Tiziana VenesioCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Candiolo, TO, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of intragenic long interspersed nuclear elements 1 (LINE1s) can generate chimeric sequences disrupting host gene transcription. Among these, L1-

Indexed as

antisense oligonucletides therapyASO theraphycancer cell deathchimeric transcriptintragenic-LINE1-derived transcript targetingL1-METMET protein knockdownMT: Oligonucleotides: Therapies and Applicationsoncogene-addicted cancer cells

Identifiers

PMID40291377
PMCPMC12032326

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.