Evidence map›Paper›PMID 40291339›Full record

ArticleLeukemia research reports2025

AL amyloidosis with elevated peripheral blood cell counts - A frequent association with liver involvement. A single-center retrospective study.

Mateusz Ziarkiewicz, Justyna Szczygieł, Marta Legatowicz-Koprowska, Joanna Drozd-Sokołowska, Piotr Boguradzki, Krzysztof Jamroziak, Grzegorz Basak

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In one paragraph

Article in Leukemia research reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mateusz ZiarkiewiczDepartment of Hematology, Transplantology and Internal Diseases, University Clinical Center of the Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Justyna SzczygiełDepartment of Cardiomyopathy, National Institute of Cardiology, 42 Alpejska Street, 04-628, Warsaw, Poland.
Marta Legatowicz-KoprowskaDepartment of Pathology, National Geriatrics, Rheumatology and Rehabilitation Institute, Spartańska 1, 02-637, Warsaw, Poland.
Joanna Drozd-SokołowskaDepartment of Hematology, Transplantology and Internal Diseases, University Clinical Center of the Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Piotr BoguradzkiDepartment of Hematology, Transplantology and Internal Diseases, University Clinical Center of the Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Krzysztof JamroziakDepartment of Hematology, Transplantology and Internal Diseases, University Clinical Center of the Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.
Grzegorz BasakDepartment of Hematology, Transplantology and Internal Diseases, University Clinical Center of the Medical University of Warsaw, 1A Banacha Street, 02-097, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: AL amyloidosis is a systemic protein misfolding disorder characterized by organ deposition of monoclonal immunoglobulin fragments, with insidious onset and progressive course. The plasma cell clone in the bone marrow is relatively small and typically does not impair hematopoiesis, in contrast to multiple myeloma. Herein we present a novel observation of increased thrombocyte, leukocyte and erythrocyte counts in a subset of AL amyloidosis patients. Material and Methods: We performed a retrospective analysis of medical records of all consecutive patients diagnosed with AL amyloidosis at the Medical University of Warsaw in years 2001-2022, which included clinical, pathological and laboratory data, as well as treatment protocols and outcomes. Results: Twenty-three patients out of 124 (18.4 %) included had elevated blood counts: 17 (13.6 %) had leukocytosis with neutrophilia, 7 (5.6 %) had thrombocytosis, whereas 2 (1.6 %) had erythrocytosis. In comparison to the remaining AL population this subgroup was characterized by younger age (median 57 vs 62 years, Conclusions: Elevated peripheral blood counts in a subset of patients with AL amyloidosis constitute a rare but significant phenomenon and appear to be associated with frequent hepatic involvement. We hypothesize that cytokine deregulation and hyposplenism may belong to its pathomechanisms.

Indexed as

AL amyloidosisErythrocytosisHepatic amyloidosisLeukocytosisMyeloproliferative neoplasmThrombocytosis

Identifiers

PMID40291339
PMCPMC12033960

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