ArticleCureus2025
Effects of Six Months of Levothyroxine Therapy on Sympathovagal Imbalance and Cardiometabolic Profile in Overt Hypothyroid Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between the Levothyroxine Therapy and the Levels of Anti-Thyroid Antibodies in Women with Hypothyroidism Due to Hashimoto's Thyroiditis-Narrative Review.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypothyroidism, a common endocrine disorder, is linked to cardiovascular risks arising from autonomic imbalance and metabolic dysregulation. While overt hypothyroidism (OH) manifests distinct thyroid hormone abnormalities, subclinical hypothyroidism (SCH) presents milder hormonal changes. Levothyroxine therapy is widely used for thyroid function restoration, but its long-term effects on autonomic and cardiovascular health in OH remain understudied. This study investigates the therapeutic effects of six months of levothyroxine treatment on autonomic function and metabolic parameters in OH patients. MATERIALS AND
methodsA follow-up study was conducted on OH patients receiving levothyroxine therapy. Participants with confounding cardiovascular comorbidities were excluded. Clinical assessments included autonomic function tests, metabolic profiling (lipid and thyroid parameters), and inflammatory/oxidative stress markers. Comparative analyses were performed against healthy controls.
resultsLevothyroxine therapy effectively restored thyroid hormone levels in OH patients. Autonomic function tests demonstrated improved parasympathetic modulation and partial sympathovagal balance recovery, though residual autonomic irregularities persisted. Lipid profiles showed marked improvement but did not fully normalize compared to controls. Inflammatory and oxidative stress markers decreased significantly post-therapy, yet remained elevated relative to healthy individuals. Statistical modeling identified oxidative stress as a key contributor to autonomic dysfunction. DISCUSSION: While levothyroxine normalized thyroid function and improved autonomic balance, incomplete resolution of metabolic and inflammatory abnormalities suggests persistent cardiovascular risks in OH patients after six months of therapy. The findings highlight the need for extended treatment durations to achieve comprehensive cardiovascular risk mitigation.
conclusionDespite therapeutic benefits, OH patients retain residual cardiovascular risks post-levothyroxine therapy, necessitating long-term monitoring. Future research should investigate optimal treatment durations and adjunct therapies to address persistent autonomic and metabolic dysfunction in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.