Evidence map›Paper›PMID 40291177›Full record

ArticleCureus2025

Dehydrated Hereditary Stomatocytosis (DHS): A Rare Inherited Hemolytic Disorder With Unusual Hypochromic Microcytic Anemia.

Badriah G Alasmari, Shady Wafa, Amjad Alsari Alqahtani, Bahaa Sameh, Lina Elzubair

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Geraniol Exerts Cytotoxic Effects in Red Cells Through CaMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Badriah G AlasmariPediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
Shady WafaPediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
Amjad Alsari AlqahtaniCollege of Medicine, King Khalid University, Abha, SAU.
Bahaa SamehPediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
Lina ElzubairPathology, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dehydrated hereditary stomatocytosis (DHS) is an autosomal dominant (AD), non-immune hemolytic disorder due to increased erythrocyte membrane cation permeability that leads to red blood cell (RBC) dehydration and lysis, which can present with a wide range of clinical findings. DHS can be present with silent-to-mild normocytic or macrocytic anemia, increased risk of thrombotic complications, or partially compensated hemolysis with few symptoms. Senicapoc has been used recently to treat DHS as it showed activity against RBC dehydration in vitro; however, its clinical outcome is not established. In this study, we report an unusual case of a 10-year-old male child who was misdiagnosed with iron deficiency anemia (IDA) for three years, despite persistent anemia and unresponsiveness to iron therapy. The diagnosis was done using whole exome sequencing (WES).

Indexed as

dehydrated hereditary stomatocytosismicrocytic hypochromic anemianon-immune hemolytic disorderpiezo1 mutationspseudohyperkalemia

Identifiers

PMID40291177
PMCPMC12034033

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.