Evidence map›Paper›PMID 40291176›Full record

ArticleCureus2025

Spinal Metastases in Diffuse Intrinsic Pontine Glioma: A Rare Presentation of Rapid Neurological Decline.

Grace E Markey, Ramesh Boggula, Ahmad Hammoud, Steven R Miller

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Grace E MarkeyDepartment of Oncology, Wayne State University School of Medicine, Detroit, USA.
Ramesh BoggulaDepartment of Oncology, Wayne State University School of Medicine, Detroit, USA.
Ahmad HammoudDepartment of Oncology, Wayne State University School of Medicine, Detroit, USA.
Steven R MillerDepartment of Oncology, Wayne State University School of Medicine, Detroit, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nine-year-old male patient with a history of diffuse intrinsic pontine glioma (DIPG) presented with an episode of acute neurological deterioration approximately 18 months following completion of a primary course of radiation therapy to the brainstem for DIPG. His symptoms at that time included weakness in the lower extremities, urinary incontinence, and respiratory failure. Magnetic resonance imaging of the brain, cervical, thoracic, and lumbar spine revealed progression of the disease with metastatic deposits involving the craniospinal axis. He subsequently underwent a course of salvage radiation therapy to the craniospinal axis. This case highlights a rare but severe manifestation of metastatic DIPG with spinal involvement.

Indexed as

brainstem tumorconformal radiation therapycraniospinal irradiation (csi)diffuse intrinsic pontine gliomasalvage radiation

Identifiers

PMID40291176
PMCPMC12032994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.