ReviewProceedings (Baylor University. Medical Center)2025
A systematic review and meta-analysis assessing the safety and efficacy of the hepatitis E virus vaccine.
Review in Proceedings (Baylor University. Medical Center), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hepatitis E vaccination: the promise of prevention.Proceedings (Baylor University. Medical Center) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatitis E virus (HEV) is a global cause of viral hepatitis. While genotypes 1 and 2 cause acute hepatitis in Asia and Africa, genotypes 3 and 4 lead to sporadic acute or chronic hepatitis in America and Europe. Pregnant women, immunosuppressed individuals, and those with chronic liver disease face a higher risk of severe outcomes. HEV recombinant vaccine is approved for outbreak use in China but awaits Food and Drug Administration approval in the USA. This systematic review and meta-analysis aims to assess the safety and efficacy of the HEV vaccine. Methods: We conducted a systematic search in Medline, Cochrane, Scopus, and Embase, employing specific terms for the recombinant HEV vaccine. Eligibility criteria involved all-age individuals receiving recombinant HEV vaccine in randomized controlled trials. Covidence software was used to screen studies, and data extraction encompassed study characteristics, baseline data, and efficacy outcomes by four reviewers. Bias evaluation was completed using Cochrane's RoB 2 tool. Statistical analysis involved use of Revman v5.4 with a random effect model, considering Results: The analysis revealed a statistically significant difference in HEV vaccine efficacy compared to placebo (odds ratio [OR]: 25.16, 95% confidence interval [CI] 9.21, 68.75, Conclusion: Our systematic review and meta-analysis demonstrates the significant and favorable impact of the recombinant HEV vaccine on the reduction of HEV cases. However, safety considerations are notable, as the vaccine is associated with a significant increase in injection-related pain and bruising. While localized adverse events were more frequent with the vaccine, there were no statistically significant differences in systemic events, serious adverse events, fever, or headache compared to placebo. These findings emphasize the overall effectiveness of the HEV vaccine in preventing HEV infections but highlight the need for careful monitoring and consideration of potential localized side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.