ArticleACS omega2025
Impact of Porous β-Tricalcium Phosphate Microspheres on Curcumin-Loaded Brushite Bone Cement for Bone Regeneration.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study aimed to create a modified injectable bone substitute (IBS) with improved osteogenic characteristics. To enhance the cement injectability and release properties of curcumin in vitro, we incorporated curcumin into β-tricalcium phosphate (β-TCP) to create the composite supplemented with sintered porous β-TCP microspheres, which maintained good injectability with an initial setting time of 5.0 ± 1.3 min and a mechanical strength of 20.67 ± 1.3 MPa for bone cements. The differentiation potential of preosteoblast (MC3T3-E1) to osteoblasts was significantly boosted by incorporating curcumin, which triggered Col I, upregulated OPN expression, and boosted alkaline phosphatase activity. Bone regeneration was hastened after the in vivo implantation of curcumin-modified brushite (BR4P2C) cement into the implanted femoral defects, and the rate of cement disintegration was accelerated. As a result, the translational application of modified BR4P2C in preliminary research has the potential to serve as an IBS with curcumin, which has an exceptional ability to repair bone lesions.
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Registered trials
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