Evidence map›Paper›PMID 40290859›Full record

ReviewJournal of tissue engineering

Strategies to overcome the limitations of current organoid technology - engineered organoids.

Xulong Fan, Kun Hou, Gaojian Liu, Ruolin Shi, Wenjie Wang, Gaofeng Liang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xulong FanSchool of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, China.
Kun HouSchool of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, China.
Gaojian LiuSchool of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, China.
Ruolin ShiInstitute of Organoids on Chips Translational Research, Henan Academy of Sciences, Zhengzhou, China.
Wenjie WangSchool of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, China.
Gaofeng LiangSchool of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, China.ORCID https://orcid.org/0000-0003-0097-0296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organoids, as 3D in vitro models derived from stem cells, have unparalleled advantages over traditional cell and animal models for studying organogenesis, disease mechanisms, drug screening, and personalized diagnosis and treatment. Despite the tremendous progress made in organoid technology, the translational application of organoids still presents enormous challenges due to the complex structure and function of human organs. In this review, the limitations of the translational application of traditional organoid technologies are first described. Next, we explore ways to address many of the limitations of traditional organoid cultures by engineering various dimensions of organoid systems. Finally, we discuss future directions in the field, including potential roles in drug screening, simulated microphysiology system and personalized diagnosis and treatment. We hope that this review inspires future research into organoids and microphysiology system.

Indexed as

bioengineeringmicroenvironmentMicrophysiological systemOrganoidorganoids-on-chips

Identifiers

PMID40290859
PMCPMC12033597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.