Evidence map›Paper›PMID 40290728›Full record

ArticleAPL bioengineering2025

High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array.

Hannah Viola, Liang-Hsin Chen, Seongbin Jo, Kendra Washington, Cauviya Selva, Andrea Li, Daniel Feng, Vincent Giacalone, Susan T Stephenson, Kirsten Cottrill and 9 more

Abstract read
In one paragraph

Article in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Liang-Hsin ChenWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0009-0007-3805-5735
Seongbin JoSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0000-0002-8107-388X
Kendra WashingtonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0000-0002-3299-0497
Cauviya SelvaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0009-0006-5211-4415
Andrea LiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Daniel FengWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0000-0002-8722-4837
Ahmad Mohammad
Evelyn WilliamsWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID https://orcid.org/0000-0002-3400-2237
Xianggui QuDepartment of Mathematics and Statistics, Oakland University, Rochester, Michigan 48309, USA.ORCID https://orcid.org/0000-0003-2448-4890
Jocelyn GrunwellDepartment of Pediatrics, Division of Critical Care Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta at Arthur M. Blank Hospital, Atlanta, Georgia 30322, USA.ORCID https://orcid.org/0000-0003-4289-6469

Funding

Extracellular vesicle-driven neutrophilic inflammation in cystic fibrosis lungsR01HL159058 · NHLBI · EMORY UNIVERSITY · PI TIROUVANZIAM, RABINDRA MARIE-JEAN · 2022 to 2025
$3.0M
Microfluidic Tissue Engineering of Small Airway InjuriesR01HL136141 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI GROTBERG, JAMES BERNARD, NEMZEK, JEAN A · 2017 to 2020
$2.9M
Graduate Training for Rationally Designed, Integrative Biomaterials - GT BioMATT32EB006343 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI TEMENOFF, JOHNNA S · 2008 to 2018
$2.2M
Longitudinal Analysis of Blood and Airway Immune Response: Precision Medicine forR01HL171627 · NHLBI · EMORY UNIVERSITY · PI Jocelyn Rebecca Grunwell · 2024 to 2026
$1.6M
Airway Immune Response in Critically Ill Children-Precision Medicine in Children At Risk for Acute Respiratory Distress SyndromeK23HL151897 · NHLBI · EMORY UNIVERSITY · PI GRUNWELL, JOCELYN REBECCA · 2020 to 2024
$888k
Mentored patient-oriented research in preschool wheezing disordersK24NR018866 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO · 2020 to 2024
$625k
Generation and Validation of a Clinical Prediction Rule for Sedative-Associated Delirium During Acute Respiratory FailureF32HL158058 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PRENDERGAST, NIALL · 2021 to 2022
$125k
NHLBI NIH HHS F32 HL158058NHLBI NIH HHS K23 HL151897NHLBI NIH HHS R01 HL136141NHLBI NIH HHS R01 HL159058NHLBI NIH HHS R01 HL171627NIBIB NIH HHS T32 EB006343NINR NIH HHS K24 NR018866
6 · The paper itself

Abstract

Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. Namely, high-throughput therapeutic assays typically exclude critical neutrophilic pathophysiology, including blood-to-lung recruitment, dysfunctional activation, and resulting impacts on the air-blood barrier. To meet the conflicting demands of physiological complexity and high throughput, we developed an assay of 96-well leukocyte recruitment in an air-blood barrier array (L-ABBA-96) that enables

Identifiers

PMID40290728
PMCPMC12033047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.