Evidence map›Paper›PMID 40290533›Full record

ArticleClinical and experimental hepatology2024

Serum dihomo-γ-linolenic acid concentration as a potential novel noninvasive biomarker for liver steatosis detection in children.

Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Marta Flisiak-Jackiewicz, Monika Kowalczuk-Krystoń, Eugeniusz Tarasów, Adrian Chabowski, Dariusz M Lebensztejn

Abstract read
In one paragraph

Article in Clinical and experimental hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia KopiczkoDepartment of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Poland.
Anna Bobrus-ChociejDepartment of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Poland.
Ewa Harasim-SymborDepartment of Physiology, Medical University of Bialystok, Poland.
Marta Flisiak-JackiewiczDepartment of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Poland.
Monika Kowalczuk-KrystońDepartment of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Poland.
Eugeniusz TarasówDepartment of Radiology, Medical University of Bialystok, Poland.
Adrian ChabowskiDepartment of Physiology, Medical University of Bialystok, Poland.
Dariusz M LebensztejnDepartment of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: To evaluate serum concentrations of dihomo-γ-linolenic acid and associated long chain n-6 polyunsaturated fatty acids (linoleic (LA), arachidonic acid (AA)) together with estimated desaturase activities in obese children with metabolic dysfunction-associated steatotic liver disease (MASLD). Material and methods: The prospective study included 57 children with obesity. MASLD was diagnosed according to the latest consensus. The total intrahepatic lipid content (TILC) was assessed by magnetic resonance proton spectroscopy ( Results: MASLD was diagnosed in 25 children. DGLA was significantly higher in children with obesity in comparison to the reference group ( Conclusions: Serum DGLA levels may be considered as a potential novel non-invasive biomarker for liver steatosis detection in children. The differences in the serum concentrations of DGLA, LA and AA between the groups and correlations found between their concentrations and other parameters suggest their potential role in pathogenesis and development of MASLD in children with obesity.

Indexed as

childrendihomo-Δ-linolenic acidMASLDmetabolic dysfunction-associated steatotic liver diseaseobesity

Identifiers

PMID40290533
PMCPMC12022613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.