Evidence map›Paper›PMID 40290486›Full record

ArticleLancet regional health. Americas2025

Immunologic changes in the peripheral blood transcriptome of individuals with early-stage chronic Chagas cardiomyopathy: a cross-sectional study.

Carolina Duque, Jaime So, Yagahira E Castro-Sesquen, Kelly DeToy, Sneider A Gutierrez Guarnizo, Fatemeh Jahanbakhsh, Edith Malaga Machaca, Monica Miranda-Schaeubinger, Indira Chakravarti, Virginia Cooper and 7 more

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In one paragraph

Article in Lancet regional health. Americas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. MaternalbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Carolina DuqueDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jaime SoDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Yagahira E Castro-SesquenDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kelly DeToyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sneider A Gutierrez GuarnizoDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Fatemeh JahanbakhshDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Edith Malaga MachacaDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Monica Miranda-SchaeubingerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Indira ChakravartiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Virginia CooperDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mary E SchmidtDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Luigi AdamoDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rachel MarcusMedStar Washington Hospital Center, Washington, D.C., USA.
Kawsar R TalaatDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Robert H GilmanDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Monica R MugnierDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Chagas Working Group

Funding

Predictors of cardiomyopathy progression in a Chagas disease cohort in BoliviaR01AI107028 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2014 to 2023
$6.6M
Infectious Diseases Training program in Bolivia: South-South Training with PeruD43TW010074 · FIC · JOHNS HOPKINS UNIVERSITY · PI ROBERT H GILMAN, Jeffrey Tornheim · 2015 to 2026
$3.5M
FIC NIH HHS D43 TW010074NIAID NIH HHS R01 AI107028
6 · The paper itself

Abstract

Background: Chagas disease, caused by the protozoan parasite Methods: We used RNA sequencing to analyse the gene expression changes in the peripheral blood of six patients with Chagas disease with early structural heart disease, four patients with Chagas disease without any signs or symptoms of disease, thirteen patients without Chagas disease with early structural heart disease, and ten patients without Chagas disease or signs of heart disease. Pathway analyses and immune cell deconvolution were employed to further elucidate the biological processes underlying early CCC development. Findings: Our analysis suggests that early CCC is associated with a downregulation of various peripheral immune response genes, including changes suggestive of reduced antigen presentation and T cell activation. Notably, these genes and processes appear to be distinct from those of non-Chagas cardiomyopathies. Interpretation: This work highlights the potential importance of the immune response in early CCC, providing insight into the early pathogenesis of this disease and how it may differ from other cardiomyopathies. The changes we have identified may serve as biomarkers of early CCC and could inform future longitudinal cohort studies of markers of disease progression and strategies for the treatment of CCC in its early stages. Funding: NIH, FONDECYT, IDSA, NSF.

Indexed as

BiomarkersCardiomyopathyChagasGene expressionImmune

Identifiers

PMID40290486
PMCPMC12033964

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.