Evidence map›Paper›PMID 40290425›Full record

ArticleFrontiers in pharmacology2025

Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.

Yan Gong, Yuzhuo Zhang, Xingda Chen, Zelin Zhou, Weicheng Qin, Yanchi Gan, Jiahui He, Jizhi Ma, Guifeng Chen, Qi Shang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yan Gong *Trauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yuzhuo Zhang *Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xingda Chen *Trauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Zelin ZhouTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Weicheng QinTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yanchi GanDepartment of Orthopedics, Ruikang Hospital Affiliated with Guangxi University of Chinese Medicine, Nanning, China.
Jiahui HeDepartment of Orthopedics, The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, China.
Jizhi MaTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guifeng ChenDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi ShangDepartment of Spinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kai TangTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Honglin ChenTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yu LiuTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
De LiangTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Gengyang ShenDepartment of Spinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaobing JiangDepartment of Spinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhaojun ChengTrauma and Orthopaedics Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The origin of intervertebral disc degeneration (IDD) is highly complex, where both cartilage endplate remodeling and vertebral osteoporosis are of utmost importance. Myristic acid (MA), a saturated fatty acid derived from nutmeg, a traditional Chinese herb, has been shown to boost memory. Additionally, its isomers have been verified to have anti-osteoporotic characteristics. However, the precise mechanism by which MA functions in relation to IDD remains unclear. Methods: Results: Using the naturally aged model, we found that MA tended to improve vertebral osteoporosis and endplate osteochondral remodeling, decreased the TRAP activity of the endplate, and alleviated IDD in naturally aged mice. Bioinformatics analysis suggested that the relationships among IDD, osteoporosis, and endplate degeneration were mainly linked to cellular senescence. Conclusion: The findings of this research suggest that MA is capable of inhibiting endplate osteochondral remodeling and vertebral osteoporosis, diminishing osteoclastogenesis to preserve bone mass, and consequently delaying IDD in naturally aged mice. Hence, MA holds the potential to serve as an alternative therapeutic approach for IDD.

Indexed as

endplate chondrocytesendplate osteochondral remodelingintervertebral disc degenerationmyristic acidosteoporosis

Identifiers

PMID40290425
PMCPMC12023261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.