Evidence map›Paper›PMID 40290218›Full record

ArticlePakistan journal of medical sciences2025

The effects of valproic acid and levetiracetam treatments on kidney functions in children with epilepsy.

Nesrin Tas, Ozge Balci, Mehmet Senes, Sukran Bicakci, Arzu Yılmaz

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Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nesrin TasNesrin Tas, MD, Department of Pediatric Nephrology, University of Health Sciences Ankara Training, Research Hospital, Ankara, Turkey.
Ozge BalciOzge Balcı, MD, Department of General Pediatrics, University of Health Sciences Ankara Training, Research Hospital, Ankara, Turkey.
Mehmet SenesMehmet Senes, MD, Department of Clinical Biochemistry, University of Health Sciences Ankara Training, Research Hospital, Ankara, Turkey.
Sukran BicakciSukran Bicakci, MD, Department of Clinical Biochemistry, University of Health Sciences Ankara Training, Research Hospital, Ankara, Turkey.
Arzu YılmazArzu Yilmaz, MD, Department of Pediatric Neurology, University of Health Sciences Ankara Training, Research Hospital, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Clinical and subclinical evidence of kidney dysfunction has been reported with the use of some anti-epileptic drugs (AEDs) in children. This study aimed to evaluate renal tubular and glomerular functions using novel biomarkers N-acetyl-β-d-glycosaminidase (NAG), Kidney Injury Molecule-1(KIM-1) and 24-hour measured creatinine clearance (mCl Methods: Fifty-one epileptic patients were included in this prospective case-control study between January 2023 and January 2024 in The Ankara Training and Research Hospital. Exclusions were made for individuals on multiple AEDs, those with incomplete data, bedridden patients, concurrent conditions (hypertension, obesity), or those using steroids or other medications. Participants had been on either VPA or LEV for at least six months. Sixteen healthy age- and sex-matched children served as the control group. Blood samples and 24-hour urine NAG, KIM-1, and mClcr measurements were collected. Results: The VPA, LEV, and control group comprised 30, 21, and 16 patients, respectively. The VPA group had higher urinary pH (6.1±0.7) and mCl Conclusion: We found VPA-associated glomerular hyperfiltration in children with epilepsy. We did not observe tubular dysfunction in patients on VPA or LEV.

Indexed as

Adverse effectsAntiepileptic drugsFanconi syndromeHyperfiltrationKidneyLevetiracetamValproic acid

Identifiers

PMID40290218
PMCPMC12022592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.