Evidence map›Paper›PMID 40290154›Full record

ArticleACS central science2025

Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport.

Zachary J Oliver, Dylan J Abrams, Luana Cardinale, Chih-Jung Chen, Gregory L Beutner, Seb Caille, Benjamin Cohen, Lin Deng, Moiz Diwan, Michael O Frederick and 11 more

Abstract read
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Zachary J OliverDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0001-6744-7454
Dylan J AbramsDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Luana CardinaleDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0001-9867-3593
Chih-Jung ChenDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0002-3309-7908
Gregory L BeutnerChemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States.ORCID https://orcid.org/0000-0001-8779-1404
Seb CailleDrug Substance Technologies, Process Development, Amgen, Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID https://orcid.org/0000-0001-5434-5483
Benjamin CohenChemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States.ORCID https://orcid.org/0000-0002-7000-9292
Lin DengSmall Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0000-0002-0132-1901
Moiz DiwanProcess Research & Development, AbbVie, 1401 Sheridan Road, North Chicago, Illinois 60064, United States.ORCID https://orcid.org/0000-0001-9019-5291
Michael O FrederickSynthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Kaid HarperProcess Research & Development, AbbVie, 1401 Sheridan Road, North Chicago, Illinois 60064, United States.ORCID https://orcid.org/0000-0003-3894-4851
Joel M HawkinsProcess Chemistry, Chemical R&D, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States.
Dan LehnherrProcess Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0001-8392-1208
Christine LuckyDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0003-1180-834X
Alex MeyerDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Seonmyeong NohDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0002-2814-5768
Diego NunezDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Kyle QuasdorfDrug Substance Technologies, Process Development, Amgen, Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID https://orcid.org/0000-0003-0151-6511
Jaykumar TeliDelivery Devices & Connected Solutions, Eli Lilly and Company, Lilly Capability Center India, Bangalore, Karnataka 560103, India.
Shannon S StahlDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0002-9000-7665
Marcel SchreierDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0002-3674-5667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organic electrosynthesis opens new avenues of reactivity and promises more sustainable practices in the preparation of fine chemicals and pharmaceuticals. The full value of this approach will be realized by taking these processes to the production scale; however, achieving this goal will require a better understanding of the influence of mass transport on reaction behavior and the interactions between reactive species and electrodes inherent to organic electrosynthesis. The limited options for cell geometries used on small scale limit elucidation of these features. Here, we show how advanced cell geometries allow us to control the interplay between reaction mechanism and mass transport, leading to improved performance of three modern organic electrosynthetic reactions. Each reaction shows a unique relationship with mass transport, highlighting the importance of understanding this relationship further to maximize the utility of organic electrosynthesis at scale.

Identifiers

PMID40290154
PMCPMC12022915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.