ArticleLancet regional health. Americas2025
Prescription opioid use and substance use disorder in US women (2006-2022): a retrospective cohort study.
Article in Lancet regional health. Americas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Research has shown that multiple deployments may have adverse effects on active-duty servicewomen and women civilian dependents of active-duty servicemembers. There is concern that the associated stress could induce sustained prescription opioid use and substance use disorder (SUD). We sought to evaluate the incidence of sustained opioid use and SUD among servicewomen and women civilian dependents during 2006-2013, a period of increased operational intensity, compared to similar individuals in 2014-2022. Methods: We employed Military Health System claims data to identify servicewomen and dependents who were diagnosed with SUD or demonstrated sustained prescription opioid use (i.e., six months of uninterrupted use). The incidence of sustained opioid use (primary outcome) and SUD associated (secondary outcome) with 2006-2013 was compared to 2014-2022 among servicewomen and dependents. Multivariable log binomial regression was used to adjust for confounding. Ethnicity was not available in our dataset. Findings: 4,876,209 individuals were included. The average age (standard deviation [SD]) of the cohorts under study were 26.6 (SD 8.2) for active duty 2006-2013, 26.0 (SD 8.0) for active duty 2014-2022, 35.3 (SD 13.1) for dependents 2006-2013 and 33.6 (SD 12.1) for dependents 2014-2022. Compared to civilian dependents in 2014-2022, servicewomen from 2006 to 2013 demonstrated an increased risk of sustained prescription opioid use (RR 1.49, 95% CI 1.46-1.53). In 2014-2022, servicewomen had a lower risk compared to dependents (RR 0.47, 95% CI 0.45-0.49), while dependents in 2006-2013 were also at higher risk (RR 1.58, 95% CI 1.56-1.60). Servicewomen in 2006-2013 were at significantly greater risk of developing SUD (RR 1.07, 95% CI 1.06-1.08). During 2014-2022, servicewomen displayed a lower risk when compared to dependents (RR 0.80, 95% CI 0.79-0.81). Dependents in 2006-2013 showed a higher risk (RR 1.24, 95% CI 1.24-1.25). Interpretation: We found significant increases in the risks of sustained opioid use and SUD among servicewomen and civilian dependents during a period of increased operational intensity (2006-2013). We believe these findings reflect the deleterious effects of emotional stress, insufficient support structures, and military sexual trauma. Funding: U.S. Department of Defense, Defense Health Agency (#HU00012320021).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.