Evidence map›Paper›PMID 40290006›Full record

ArticleNutrients2025

Qi Zhang, Shuang Xie, Qiu Zhong, Xinyue Zhang, Liufang Luo, Qian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Immunomodulatory Properties of the Cyclic Lipopeptide Surfactin.Journal of microbiology and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi ZhangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Shuang XieMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Qiu ZhongMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Xinyue ZhangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Liufang LuoMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Qian YangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.ORCID 0000-0002-2349-0028

Funding

the National Key Research and Development Program of China 2022YFD1800805-02
6 · The paper itself

Abstract

backgroundEnteric and diarrheal diseases pose a significant threat to infant health, highlighting the importance of immune defenses in early life, especially maternal protection, in establishing a robust gastrointestinal environment. Surfactin, a bioactive peptide from

methodsTwenty-eight gravid mice were randomly categorized into two cohorts and were given surfactin or not in drinking water from one week after conception to 21 days postpartum. Cross-fostering experiments were conducted within 12 h after birth. Pups from the surfactin-supplemented dams were fostered and nursed by the control dams, while the pups from the control dams were nursed by the surfactin-supplemented dams.

resultsThe findings show that the pups from the surfactin-supplemented dams had increased body weight, improved intestinal morphology with longer villus and deeper crypts, the upregulation of genes related to mucins and antimicrobial peptides, and an increase in IgA

conclusionsThis research contributes to understanding how maternal interference can modulate breast milk composition, influence infant gastrointestinal development and immunity, and provide nutritional strategy insights.

Indexed as

Bacillus subtilisInflammationIntestinesLipopeptidesMilkPeptides, CyclicAnimalsAnimals, NewbornDietary SupplementsFemaleIntestinal MucosaMaleMiceOxidative StressPregnancyLipopeptidesPeptides, Cyclicsurfactin peptideBacillus subtilis extractbreast milkimmune modulationintestinal inflammatory injuriesneonatal intestinal developmentsurfactin

Identifiers

PMID40290006
PMCPMC11945067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.