Evidence map›Paper›PMID 40289919›Full record

ArticleDevelopment and psychopathology2025

Childhood exposure to danger increases Black youths' alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis.

Steven R H Beach, Sierra E Carter, Mei Ling Ong, Justin A Lavner, Steven M Kogan, Katherine B Ehrlich, Man-Kit Lei, Ronald L Simons, Olutosin Adesogan, Frederick X Gibbons and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steven R H BeachDepartment of Psychology, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0001-8053-7761
Sierra E CarterDepartment of Psychology, Georgia State University, USA.ORCID https://orcid.org/0000-0003-3842-3175
Mei Ling OngCenter for Family Research, University of Georgia, Athens, GA, USA.
Justin A LavnerDepartment of Psychology, University of Georgia, Athens, GA, USA.
Steven M KoganCenter for Family Research, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0002-9562-5980
Katherine B EhrlichDepartment of Psychology, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0002-8958-6161
Man-Kit LeiDepartment of Sociology, University of Georgia, Athens, GA, USA.
Ronald L SimonsDepartment of Sociology, University of Georgia, Athens, GA, USA.
Olutosin AdesoganDepartment of Psychology, University of Georgia, Athens, GA, USA.
Frederick X GibbonsDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.ORCID https://orcid.org/0000-0003-1205-1481
Meg GerrardDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Robert A PhilibertDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.

Funding

Research Support CoreP50DA051361 · NIDA · UNIVERSITY OF GEORGIA · PI EHRLICH, KATHERINE BABCOCK · 2020 to 2024
$9.7M
Contextual and Health Behavior Effects on Epigenetic Aging Among African AmericansR01CA220254 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI BEACH, STEVEN R, GIBBONS, FREDERICK X · 2018 to 2022
$3.5M
Stress, Weathering, and Blood-Based Biomarkers of Alzheimer’s Disease: A Longitudinal Study of Low Income, Aging African AmericansRF1AG077386 · NIA · UNIVERSITY OF GEORGIA · PI MIELKE, MICHELLE M, SIMONS, RONALD L · 2022 to 2023
$3.2M
NCI NIH HHS R01 CA220254NIA NIH HHS RF1 AG077386NIDA NIH HHS P50 DA051361
6 · The paper itself

Abstract

Using the dual-pathway framework (Beach et al., a), we tested a Neuro-immune Network (NIN) hypothesis: i.e., that chronically elevated inflammatory processes may have delayed (i.e., incubation) effects on young adult substance use, leading to negative health outcomes. In a sample of 449 participants in the Family and Community Health Study who were followed from age 10 to age 29, we examined a non-self-report index of young adult elevated alcohol consumption (EAC). By controlling self-reported substance use at the transition to adulthood, we were able to isolate a significant delayed (incubation) effect from childhood exposure to danger to EAC (β = -.157, p = .006), which contributed to significantly worse aging outomes. Indirect effects from danger to aging outcomes via EAC were: GrimAge (IE = .010, [.002, .024]), Cardiac Risk (IE = -.004, [-.011, -.001]), DunedinPACE (IE = .002, [.000, .008]). In exploratory analyses we examined potential sex differences in effects, showing slightly stronger incubation effects for men and slightly stronger effects of EAC on aging outcomes for women. Results support the NIN hypothesis that incubation of immune pathway effects contributes to elevated alcohol consumption in young adulthood, resulting in accelerated aging and elevated cardiac risk outcomes via health behavior.

Indexed as

alcoholcardiac riskDangerDNAm-based agingInflammation

Identifiers

PMID40289919
PMCPMC12353583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.