SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Genetic and environmental risk factors for dementia in African adults: A systematic review.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Cytokines and immune biomarkers in neurodegeneration and cognitive function: A systematic review among individuals of African ancestry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Beyond Diagnosis: Characterising Symptom Profiles of Dementia in a Resource-Limited South African Clinical Setting.Healthcare (Basel, Switzerland) · 2026Article
- The role of polygenic risk in Alzheimer's disease prediction for African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Translational potential of medicinal plants for Alzheimer's disease: integrated evidence from molecular mechanisms to preclinical and clinical findings.Natural products and bioprospecting · 2026Review
- The incidence of dementia in populations around the globe.Current opinion in psychiatry · 2026Review
- The Cognitive and Neuroimaging for Neurodegenerative Disorders Study (CogNID): design and initial findings from real-world clinical practice.Frontiers in psychiatry · 2025Article
- ABCA7-80 moderates vascular stiffness-p-tau217 association in older African Americans.Alzheimer's & dementia (New York, N. Y.)Article
- Population disparities in Alzheimer's disease: A systematic review of fluid and neuroimaging biomarkers.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia, a leading cause of global mortality, disproportionately impacts sub-Saharan Africans due to complex genetic and environmental interactions. This systematic review evaluated dementia risk factors among sub-Saharan Africans, identifying significant genetic and environmental influences using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The ATP-binding cassette subfamily A member 7 (ABCA7) gene, linked to dementia in African Americans, and unique genetic variants like those in A-kinase anchor protein 9 (AKAP9) and cytidine deaminase (CDA) genes, emerge as potential contributors. Conversely, apolipoprotein E (APOE) ε4 shows lesser impact in older sub-Saharan Africans. Environmental findings highlight that exposure to air pollution, including nitrogen dioxide and particulate matter increases the likelihood of dementia. These findings highlight the role of genetic and environmental diversity in shaping dementia risk profiles. Strategies such as training health-care professionals, enhancing funding for research, combating stigma through awareness campaigns, and fostering global collaborations are vital to ensure African representation in dementia studies. These efforts aim to improve the knowledge of dementia tailored to sub-Saharan Africa's needs. HIGHLIGHTS: The ATP-binding cassette subfamily A member 7 (ABCA7) gene is strongly associated with dementia risk, particularly in African American populations. Apolipoprotein E (APOE) ε4, a well-established risk factor for Alzheimer's disease in Western populations, has a lesser impact in older sub-Saharan Africans, suggesting unique genetic-environment interactions. Exposure to air pollutants, such as nitrogen dioxide and particulate matter, significantly increases dementia risk. The development of dementia in sub-Saharan Africans is influenced by complex interactions between genetic predispositions and environmental exposures, emphasizing the need for tailored prevention strategies.
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