ArticleCirculation2025
Splenic CD169
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Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed.
- Macrophages and the Survival of Cardiomyocytes After Myocardial Infarction.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Extracellular Vesicles Mediate Activation and Trafficking of Splenic Immune Cells to the Heart Post-Myocardial Infarction.bioRxiv : the preprint server for biology · 2026Article
- Dapagliflozin binds PRMT7 to inhibit p38 MAPK phosphorylation and macrophage foam cell formation in atherosclerosis.iScience · 2026Article
- The spleen-heart crosstalk in cardiovascular disease: integrating neural, immune, and secretory pathways.Acta pharmacologica Sinica · 2026Review
- Inflammation and wound healing: a comprehensive overview of mechanisms, therapeutic strategies, and translational perspectives.Biomarker research · 2026Review
- Estrogen Stabilizes Interferon-Inducible Genes During Skeletal Muscle Regeneration.Biological research for nursing · 2026Article
- Single cell transcriptome signatures and cell-cell interactions associated with sarcoidosis in lung immune cell populations.Frontiers in immunology · 2026Article
- Targeting the heart-immune axis after myocardial infarction: from inflammation to immunomodulation.Frontiers in cardiovascular medicine · 2026Review
- TIM-4International journal of biological sciences · 2026Article
- Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac injury resolution via de-repression of Anxa1.Theranostics · 2026Article
- Efferocytosis in myocardial infarction: the regulatory core from inflammation resolution to cardiac repair.Frontiers in immunology · 2026Review
- Bone marrow-derived CD169Experimental & molecular medicine · 2025Article
- Evolving tumor microenvironment: Driving cancer initiation and progression in cardiovascular diseases.iScience · 2025Review
- Targeting Extramedullary Hematopoiesis and Cardiac Immune Homing to Encourage Cardiac Healing After Myocardial Infarction.Circulation · 2025Article
Corrections and comments
- Commented on by
- Update ofSplenic CD1692024
Authors and funding
12 authors.
Mohamed Ameen IsmahilDivision of Cardiology, Department of Medicine, Washington University in St Louis, MO (M.A.I., S.R., G.R., T.H., S.D.P.).ORCID 0000-0002-7452-6123
Guihua ZhouDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Shreya RajasekarDivision of Cardiology, Department of Medicine, Washington University in St Louis, MO (M.A.I., S.R., G.R., T.H., S.D.P.).
Min GaoDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Shyam S BansalDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.ORCID 0000-0001-9179-6478
Bindiya PatelDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Nita LimdiNeurology (N.L.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Min XieDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.ORCID 0000-0002-2967-3490
Sergey AntipenkoDepartments of Medicine, Cardiovascular Disease (M.A.I., G.Z., M.G., S.S.B., B.P., M.X., S.A., G.R., T.H., S.D.P.), University of Alabama at Birmingham. Dr Bansal is currently affiliated with the Heart and Vascular Institute, Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.ORCID 0000-0002-5079-6735
Gregg RokoshDivision of Cardiology, Department of Medicine, Washington University in St Louis, MO (M.A.I., S.R., G.R., T.H., S.D.P.).
Tariq HamidDivision of Cardiology, Department of Medicine, Washington University in St Louis, MO (M.A.I., S.R., G.R., T.H., S.D.P.).
Sumanth D PrabhuDivision of Cardiology, Department of Medicine, Washington University in St Louis, MO (M.A.I., S.R., G.R., T.H., S.D.P.).ORCID 0000-0002-7247-7241
Funding
Macrophage Circadian Clock Disruption and Inflammation in Heart FailureR01HL147549 · NHLBI · WASHINGTON UNIVERSITY · PI PRABHU, SUMANTH D, YOUNG, MARTIN E · 2019 to 2022
$2.3MCardiac Macrophages as Disease Drivers in Chronic Ischemic Heart FailureR01HL157999 · NHLBI · WASHINGTON UNIVERSITY · PI PRABHU, SUMANTH D · 2021 to 2024
$2.1MCardiac Mesenchymal Stem Cells and Myocardial Fibrosis: Role of Platelet Derived Growth Factor Receptor SignalingR01HL137046 · NHLBI · WASHINGTON UNIVERSITY · PI HAMID, TARIQ · 2018 to 2021
$1.5MSplenic Marginal Zone Macrophages in Chronic Ischemic Heart FailureR01HL125735 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PRABHU, SUMANTH D · 2015 to 2018
$1.5MPatient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2MBeta-hydroxybutyrate Protects Mitochondria During Cardiac Ischemia Reperfusion InjuryR03HL141620 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI XIE, MIN · 2018 to 2019
$149kBLRD VA I01 BX002706NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R01 HL125735NHLBI NIH HHS R01 HL137046NHLBI NIH HHS R01 HL147549NHLBI NIH HHS R01 HL157999NHLBI NIH HHS R03 HL141620
Abstract
backgroundFidelity of wound healing after myocardial infarction (MI) is an important determinant of subsequent adverse cardiac remodeling and failure. Macrophages derived from infiltrating Ly6C
methodsWe used a variety of in vivo murine models and orthogonal approaches, including surgical MI, flow cytometry and single-cell RNA sequencing, lineage tracing and cell tracking, splenectomy, parabiosis, cell adoptive transfer, and functional characterization, to establish an essential role for splenic CD169
resultsSplenic CD169
conclusionsSplenic CD169
Indexed as
MacrophagesMyocardial InfarctionSialic Acid Binding Ig-like Lectin 1SpleenWound HealingAnimalsDisease Models, AnimalFemaleHumansMaleMembrane ProteinsMiceMice, Inbred C57BLMonocytesMembrane ProteinsSialic Acid Binding Ig-like Lectin 1Siglec1 protein, mouseTIM-4 protein, mouseheart failureinflammationmacrophagesmyocardial infarctionspleen
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.