ArticleMovement disorders : official journal of the Movement Disorder Society2025
Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Acute and Chronic Local Field Potential Recordings in Dystonia-A Systematic Review.Movement disorders clinical practice · 2026Review
- GABAB1R: A molecular bridge linking deep brain stimulation to antidepressant effects--A commentary on "NAcLat-DBS reduces GABAB1R expression of dopamine neurons to correct depressive symptoms in CMS mice".Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Pallidal Evoked Resonant Neural Activity as a Candidate Biomarker for Deep Brain Stimulation in Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
backgroundDeep brain stimulation (DBS) elicits oscillatory local field potentials in patients with Parkinson's disease (PD) and other movement disorders. Greater knowledge about the fast dynamics of these neural responses could shed light on circuit pathophysiology and inform novel approaches to neuromodulation therapies.
objectivesTo compare short-term neuroplasticity in the globus pallidus interna (GPi) and the subthalamic nucleus (STN), the canonical functional targets for PD and dystonia.
methodsDuring surgery for DBS lead implantation, we delivered pairs of stimuli across various interstimulus intervals and amplitudes and recorded DBS-evoked responses from unused contacts on the lead. After stimulus artifact removal, we contrasted the magnitude and timing of the local responses by paired pulse interval and brain target. Additionally, we compared the amplitudes of the DBS-evoked potentials versus resting local field potentials at the same recording site.
resultsIn 14 patients undergoing STN DBS and 9 undergoing GPi DBS, evoked potentials in the STN exhibited greater amplitudes than those in the GPi. However, paired pulse neuroplasticity was larger in the GPi than in the STN. Otherwise, the responses at both sites exhibited similar paired pulse hastening and refractoriness, onset latencies, and frequencies measured by the first two peaks.
conclusionsSingle and paired DBS pulses elicit local oscillations with larger amplitudes in the STN than in the GPi. Otherwise, the responses display similar time dynamics and short-term neuroplasticity. These findings could inform therapeutic innovation with future DBS systems that utilize sensing technologies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.