Evidence map›Paper›PMID 40289639›Full record

ArticleAnnals of medicine2025

Serum regenerative islet-derived protein 1α: a novel and sensitive biomarker for endoscopic disease activity in ulcerative colitis.

Xiaoduan Zhuang, Huiyue Jiang, Tingting Fan, Xiaoqi Luo, Xuanfang Zhong, Jian Guo, Yaxian Zhou, Bingsheng Li, Xinying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoduan ZhuangDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Huiyue JiangDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Tingting FanDepartment of Gastroenterology, The People's Hospital of Baoan Shenzhen, Shenzhen, China.
Xiaoqi LuoDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xuanfang ZhongDepartment of Gastroenterology, Huizhou First Hospital, Huizhou, China.
Jian GuoSenboll Biotechnology Co., Ltd, Pingshan Bio-Pharmacy Business Accelerator, Shenzhen, Guangdong, China.
Yaxian ZhouSenboll Biotechnology Co., Ltd, Pingshan Bio-Pharmacy Business Accelerator, Shenzhen, Guangdong, China.
Bingsheng LiDepartment of Gastroenterology, Huizhou First Hospital, Huizhou, China.
Xinying WangDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0003-2956-0856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMucosal healing (MH) has established as a long-term therapeutic goal for inflammatory bowel disease (IBD). Regenerative Islet-derived Protein 1α (reg1α) was reported to be closely related to gastrointestinal mucosal injury; however, its potential in monitoring MH remains unexplored.

methodsSerum reg1α levels were quantified in 156 consecutive IBD patients (January 2021-December 2023) and stratified by endoscopic findings into MH (

resultsA total of 136 patients (85 with CD and 51 with UC) were finally included. Serum reg1α levels were significantly correlated with endoscopic activity. Patients in NMH group demonstrating markedly higher reg1α levels than those in MH group (92.6

conclusionReg1α represents as a novel and sensitive biomarker of endoscopic disease activity in patients with UC, even in patients with non- or mild clinical symptoms or normal CRP levels.

Indexed as

Colitis, UlcerativeCrohn DiseasePancreatitis-Associated ProteinsAdultAgedBiomarkersC-Reactive ProteinFemaleHumansIntestinal MucosaLithostathineMaleMiddle AgedROC CurveSensitivity and SpecificitySeverity of Illness IndexBiomarkersC-Reactive ProteinLithostathinePancreatitis-Associated ProteinsREG1A protein, humanC-reactive proteinMucosal healingregenerative islet-derived protein 1αulcerative colitis

Identifiers

PMID40289639
PMCPMC12039404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.