ArticleThe Journal of neuropsychiatry and clinical neurosciences2025
Apathy in Parkinson's Disease: A Diagnostic Conundrum Explored in a Cohort Characterization Study.
Article in The Journal of neuropsychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Altered static and dynamic functional network connectivity in Parkinson's disease: A multisite functional magnetic resonance imaging study.IBRO neuroscience reports · 2026Article
- Apathy in dementia with Lewy bodies: Frequency, correlates, and impact on patient and caregiver experiences.Parkinsonism & related disorders · 2026Article
- Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis.Movement disorders clinical practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveApathy is a prevalent neuropsychiatric feature of Parkinson's disease (PD), marked by reduced goal-directed behavior. Apathy is distinct from depression and significantly affects daily functioning and quality of life. Despite this, the DSM-5 does not acknowledge apathy as its own diagnostic category. The authors sought to examine how individuals with PD who score high on a self-report apathy scale are diagnostically classified by psychiatrists within a clinical setting.
methodsFifty-five individuals with "pure apathy" were identified from a larger clinical convenience sample of 458 patients with PD. The pure-apathy group consisted of patients who scored above the clinical cutoff on a self-report measure of apathy but whose symptoms were below the cutoffs for depression and anxiety measures. These patients also received a standard clinical psychiatric evaluation using DSM-5 criteria. The authors examined the diagnoses provided by psychiatrists who were unaware of results of the mood scales.
resultsMore than half (53%) of the pure-apathy group had received no psychiatric diagnosis. The remainder had received the following diagnoses: anxiety (27%), depression (5%), comorbid depression and anxiety (5%), and other psychiatric diagnoses (9%). The most common anxiety diagnoses were unspecified or other specified anxiety disorders and generalized anxiety disorder. The most common depression diagnoses were unspecified or other specified depressive disorders.
conclusionsThis study highlights a gap in diagnosing psychiatric conditions in PD, specifically for individuals with primarily apathetic presentations. More than 50% of PD patients in the pure-apathy group had received no psychiatric diagnosis, possibly resulting in unmet clinical needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.