ArticleJournal of medical virology2025
Serological Response to Mpox and Direct Virus Detection in Asymptomatic Patient Prior to the First Diagnosed Case: A Retrospective Study of the 2022 Montpellier Epidemic.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mpox seroprevalence among sex workers and men who have sex with men preceding sustained urban outbreak in the Democratic Republic of the Congo.Epidemiology and infection · 2026Article
- Mpox Seroprevalence in General Population Groups in South Kivu, Democratic Republic of the Congo: A Comparative Description Before and During the Clade Ib Outbreak.Open forum infectious diseases · 2026Article
- Serological Survey in African Nonhuman Primate Species in Cameroon and the Democratic Republic of the Congo Reveals Low Overall Seroprevalence to Mpox Virus.The Journal of infectious diseases · 2026Article
- Sero-genomic evidence for occult mpox exposure in healthy Nigerian adults.Nature communications · 2026Article
- Serological evidence uncovers undocumented mpox exposure in febrile patients in Nigeria.Frontiers in public health · 2026Article
- Diagnostic Advances and Public Health Challenges for Monkeypox Virus: Clade-Specific Insight and the Urgent Need for Rapid Testing in Africa.Diagnostics (Basel, Switzerland) · 2025Review
- Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mpox (formerly monkeypox) outbreak in 2022 presented unprecedented challenges, including widespread transmission in non-endemic regions, particularly among men who have sex with men. This study examines Mpox infections in Montpellier, France, focusing on diagnostic testing, serological profiles, and potential asymptomatic cases, based on data from Montpellier University Hospital. We retrospectively analyzed results from 91 patients tested positive for Mpox DNA. Antibody responses were monitored using novel Mpox virus peptide-based serological assays. Our findings highlight that MPXV antibodies can develop early in infection, peaking within 2 weeks to 3 months, though responses varied by antigen type. Additionally, asymptomatic Mpox infections were suggested, with virus detected in blood, urine, anal, oral and genital swabs screened Sexual Transmitted Infection samples. Notably, viral presence was confirmed in Montpellier samples as early as mid-May 2022, before the first known symptomatic case in Hospital, in the same period as the first official case in France. This study underscores the need for expanded screening in high-risk clinics to control Mpox spread and supports the potential utility of serological assays for broad immune profiling. Enhanced diagnostic tools and proactive surveillance in sexual health settings are recommended to improve outbreak response and prevent further transmission.
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