ArticleNMR in biomedicine2025
Coil Combination Using OpTIMUS Results in Improved Signal-to-Noise Ratios of In Vivo MR Spectra Acquired at 7 T.
Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Magnetic resonance spectroscopy (MRS) enables noninvasive quantification of metabolites, but its utility in vivo can be limited by low signal-to-noise ratios (SNRs) and long acquisition times. The use of ultrahigh-field (UHF) strengths (> 3 T) combined with multichannel phased receive arrays can improve spectral SNR. A crucial step in the use of multichannel arrays is the combination of spectra acquired from individual coil channels. We previously developed a coil combination method at 3 T, optimized truncation to integrate multichannel MRS data using rank-R singular value decomposition (OpTIMUS), which uses noise-whitened windowed spectra and iterative rank-R singular value decomposition (SVD) to combine multichannel MRS data. Here, we evaluated OpTIMUS for combination of MR spectra acquired using a multichannel phased array at 7 T and compared spectral SNR and metabolite quantification with spectra combined using whitened SVD (WSVD), signal/noise squared (S/N
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