Evidence map›Paper›PMID 40289540›Full record

ArticleJournal of cellular and molecular medicine2025

Preventive Effects of Vanillic Acid Against Lung Inflammation and Oxidative Stress Induced by Dust Particles in Wistar Rats.

Seyedeh Samira Hosseinzadeh, Nazanin Balighi, Jafar Saeidi, Mohsen Azimi-Nezhad, Mahnaz Mohtashami, Zahra Hojat Bonab, Mansoureh Dehghani, Mona Ariamanesh, Abolfazl Naimabadi, Ahmad Ghasemi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Seyedeh Samira HosseinzadehDepartment of Biology, School of Basic Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
Nazanin BalighiDepartment of Biology, School of Basic Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
Jafar SaeidiDepartment of Physiology, School of Basic Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
Mohsen Azimi-NezhadHealthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Mahnaz MohtashamiDepartment of Biology, School of Basic Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
Zahra Hojat BonabDepartment of Microbiology, School of Basic Science, Bonab Branch, Islamic Azad University, Bonab, Iran.
Mansoureh DehghaniDepartment of Radiation Oncology, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Mona AriamaneshDepartment of Pathology, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Abolfazl NaimabadiDepartment of Environmental Health Engineering, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Ahmad GhasemiDepartment of Biochemistry, Nutrition and Food Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Amir Abbas Momtazi-BorojeniDepartment of Medical Biotechnology, School of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.ORCID 0000-0002-4376-1083

Funding

Islamic Azad University, Neyshabur Branch IR, IAU.MSHD.REC 1401.002
6 · The paper itself

Abstract

To evaluate dose-dependent cytotoxicity effects of indoor dust particles (DPs) collected from Neyshabur, Iran, in vitro on A545 cells and in vivo on lungs of healthy male Wistar rats, as well as the antioxidant effects of vanillic acid (VA) against DP inhalation. Heavy metal levels in DPs collected from high-traffic (HT), medium-traffic, low-traffic or rural (LT) zones were measured, and their cytotoxicity effects were evaluated by MTT assay. In vivo evaluations were conducted after rats were exposed to DPs collected from HT or LT in the presence or absence of VA. Exposure to DPs increased the activity of serum superoxide dismutase; the serum level of malondialdehyde; and mRNA expression of TNFα, IL6, CXCL15 and CYP1A1 in the lung homogenate groups receiving HT and LT compared to the control group. DP effects in the groups receiving HT were higher than those of LT. Concomitant VA intake attenuated the adverse effects mediated by DPs in the HT and LT groups. DPs had adverse effects on the lungs of healthy rats, probably because of the accumulated oxidative stress agents. VA could ameliorate the effects of DPs and may be considered as a protective substance against the undesirable effects of DPs.

Indexed as

DustOxidative StressPneumoniaVanillic AcidAnimalsAntioxidantsHumansLungMaleMalondialdehydeParticulate MatterRatsRats, WistarSuperoxide DismutaseAntioxidantsDustMalondialdehydeParticulate MatterSuperoxide DismutaseVanillic Acidenvironmental pollutionheavy metalinflammationlungoxidative stressvanillic acid

Identifiers

PMID40289540
PMCPMC12034852

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.