Evidence map›Paper›PMID 40289410›Full record

ArticleJournal of clinical and experimental neuropsychology2025

Using objective and subjective measures of mind wandering to predict progression to development of cognitive impairment and test associations with Alzheimer disease biomarkers.

Matthew S Welhaf, David A Balota, Suzanne E Schindler, John C Morris, Jason Hassenstab, Andrew J Aschenbrenner

Abstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew S WelhafDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
David A BalotaDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Suzanne E SchindlerDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
John C MorrisDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Jason HassenstabDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Andrew J AschenbrennerDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
AGING AND DEVELOPMENTT32AG000030 · NIA · WASHINGTON UNIVERSITY · PI DENISE HEAD, Jeffrey M Zacks · 1985 to 2026
$9.7M
Within-person dynamics of cognition and personality in healthy aging and Alzheimer's disease.K01AG071847 · NIA · WASHINGTON UNIVERSITY · PI ASCHENBRENNER, ANDREW · 2021 to 2025
$526k
NIA NIH HHS K01 AG071847NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS T32 AG000030
6 · The paper itself

Abstract

introductionMind wandering decreases in healthy aging, and in some cases, it is further reduced in Alzheimer disease (AD). However, little is known about how mind wandering changes during the preclinical phase of AD, which is a critical period for intervention. The present study aims to provide novel evidence for the utility of objective and subjective measures of mind wandering in evaluating the risk of developing cognitive impairment and their association with AD biomarkers.

methodsParticipants (

resultsObjective and subjective mind wandering significantly differed between progressors and cognitively stable participants at baseline and predicted likelihoods of progression. Moreover, baseline subjective mind wandering predicted progression beyond standard neuropsychological measures. Longitudinal models indicated that biomarker negative, but not positive, participants showed a significant reduction in RT CoV over time, possibly reflecting practice-related changes in performance. There were no longitudinal associations with subjective mind wandering.

conclusionsMind wandering is a common activity and may reflect a healthy cognitive system in older age. Subjective measures of mind wandering may be useful in predicting the later onset of cognitive impairment, while objective measures may be more sensitive to longitudinal changes.

Indexed as

Alzheimer DiseaseAttentionCognitive DysfunctionDisease ProgressionThinkingAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsReaction TimeAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer diseasebiomarkersMind wanderingprogressionreaction time variability

Identifiers

PMID40289410
PMCPMC12129468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.