Evidence map›Paper›PMID 40289407›Full record

ArticleProteomics2025

A Non-Metaproteomics Researchers' View on Metaproteomics in Microbiome Research.

Velma T E Aho, Laure-Alix Clerbaux, Anne Kupczok, Bree Tillett, Neha Garg, Jannie G E Henderickx

Erratum issuedAbstract read
In one paragraph

Article in Proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Velma T E AhoFaculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway.
Laure-Alix ClerbauxLaboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium.
Anne KupczokBioinformatics Group, Wageningen University & Research, Wageningen, the Netherlands.
Bree TillettFrazer Institute, Faculty of Medicine, The University of Queensland Australia, Brisbane, Australia.
Neha GargSchool of Chemistry and Biochemistry, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
Jannie G E HenderickxCenter for Microbiome Analyses and Therapeutics, Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-6533-0324

Funding

Halogenation Biochemistry in Human and Environmental HealthR35GM142882 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI AGARWAL, VINAYAK · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142882
6 · The paper itself

Abstract

Metaproteomics, an emerging field among the omic techniques, holds great promise for unraveling the function of microbiomes in host health and our environment. Metaproteomics can also be a valuable addition to multiomics studies of the microbiome, complementing genome-resolved metagenomics, metatranscriptomics, and metabolomics. The potential advancements from metaproteomics and multiomics research touch a breadth of disciplines, including ecology, biochemistry, immunology, medical microbiology, cell physiology, and medicine, and could lead to both fundamental and applied discoveries. However, there are significant roadblocks to widespread adoption of metaproteomics among microbiome researchers. In this Viewpoint article, we highlight the pivotal role of metaproteomics in microbiome research by showcasing its advantages, exploring opportunities to overcome challenges, and paving the way for its broader adoption as a mainstream technique. We hope that the recommendations provided in this Viewpoint article will inspire new, beneficial collaborations between proteomics experts, algorithm and infrastructure developers, biochemists, cell biologists, and microbiologists, enabling the construction of a knowledge base of microbiome function that can have an immediate and direct impact on host health and the environment.

Indexed as

MetagenomicsMicrobiotaProteomicsHumansMetabolomicsfunctional analysismetagenomicsmetaproteomicsmicrobiomemultiomics

Identifiers

PMID40289407
PMCPMC12456258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.