ArticleChemMedChem2025
Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization.
Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Ubiquitin-specific protease 7 (USP7) is a key deubiquitinating enzyme involved in tumor suppression, DNA repair, and epigenetic regulation. Given its critical role in cancer progression, USP7 has emerged as an attractive therapeutic target. Using similarity-based ligand screening, structurally related analogs of previously identified and validated hit compounds by our research group are selected and grid-based docking simulations are performed, prioritizing molecules with high binding affinity (docking scores < -8.0 kcal mol
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