Evidence map›Paper›PMID 40289176›Full record

ArticleInflammation and regeneration2025

NRP2

Kotaro Tanaka, Rintaro Yoshikawa, Satoru Miyagi, Takashi Suyama, Hiromi Miyauchi, Yuko Kato, Kenichi Miyamoto, Yumi Matsuzaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation and regeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kotaro TanakaDepartment of Life Science, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan.
Rintaro YoshikawaDepartment of Life Science, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan. rintaro@med.shimane-u.ac.jp.
Satoru MiyagiDepartment of Biochemistry, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan.
Takashi SuyamaDepartment of Life Science, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan.
Hiromi MiyauchiPuREC Co., Ltd, 89 - 1 Enya, Izumo, Shimane, 693 - 0021, Japan.
Yuko KatoDepartment of Biochemistry, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan.
Kenichi MiyamotoDepartment of Life Science, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan.
Yumi MatsuzakiDepartment of Life Science, Faculty of Medicine, Shimane University, 89 - 1 Enya, Izumo, Shimane, 693 - 8501, Japan. matsuzak@med.shimane-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe clinical application of mesenchymal stem cells (MSCs) has garnered attention due to their remarkable capacity to differentiate into adipocytes, chondrocytes, and osteoblasts. However, the quality of MSC culture varies from batch to batch, which poses challenges in ensuring consistent cellular quality across batches. Consequently, it becomes imperative to identify specific markers that can distinguish superior and slightly inferior MSCs.

methodsHuman bone marrow-derived MSC clones were isolated and subjected to flow cytometry analysis to assess the expression of NRP2, VEGFR, and plexinA1. The osteogenic and adipogenic differentiation potentials were evaluated using Alizarin Red S and Oil Red O staining, respectively. Furthermore, the migration capacity was assessed through the scratch healing assay.

resultsNine out of twenty MSC clones significantly expressed NRP2. NRP2-expressing MSC clones (NRP2

conclusionIn contrast to NRP2

Indexed as

Bone marrowFlow cytometryMesenchymal stem cellsNeuropilin- 2Regenerative medicineStemness

Identifiers

PMID40289176
PMCPMC12036193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.