Evidence map›Paper›PMID 40289160›Full record

ArticleScientific reports2025

Long-term systemic androgen deprivation partially modulates neuroinflammation in male App

Kasumi Maekawa, Akira Sobue, Okiru Komine, Yuko Saito, Shigeo Murayama, Takaomi C Saido, Takashi Saito, Koji Yamanaka

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kasumi MaekawaDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Akira SobueDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Okiru KomineDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Yuko SaitoDepartment of Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, 173-0015, Japan.
Shigeo MurayamaBrain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, 173-0015, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, 351-0198, Japan.
Takashi SaitoDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Koji YamanakaDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan. yamanaka.koji.p4@f.mail.nagoya-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP24wm0425014Japan Science and Technology Agency JPMJMS2024
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the leading neurodegenerative disease manifesting cognitive impairment. Its procession is regulated by activated glial cell-mediated neuroinflammation. Although estrogen deprivation is a known risk factor for AD in females, the impact of androgen deprivation on AD pathology in males, particularly regarding neuroinflammation, remains unclear. This study investigates the effects of long-term systemic androgen deprivation on AD pathology, including glial cell-specific gene expression, amyloid β (Aβ) pathology, and cognitive function in male castrated App

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAndrogensNeuroinflammatory DiseasesAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalHumansMaleMiceMice, TransgenicMicrogliaOrchiectomyReceptors, AndrogenAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAndrogensReceptors, AndrogenAlzheimer’s diseaseAndrogenCastrationMicrogliaNeuroinflammation

Identifiers

PMID40289160
PMCPMC12034793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.