Chacma baboon natural anticoagulants and factor VIII activities.

Quintin Andre van Staden, Sarah Meiring Muriel, Conradie Charmaine, Joubert Jaco

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Quintin Andre van StadenDepartment of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa. vanstadequintin4@gmail.com.

Sarah Meiring MurielDepartment of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Conradie CharmaineDepartment of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Joubert JacoDepartment of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-human primates are useful models of human haemostasis, but distinctions do exist. These differences are essential to identify and quantify to better characterise the Chacma baboon's coagulation system. The Chacma baboon's factor VIII and natural anticoagulants were characterised and compared to human reference ranges. Parameters were measured using commercial chromogenic and clot-based assays, in 40 Rhesus negative, ABO typed, male and female Chacma baboon platelet poor plasma samples. Free protein S concentration, protein C, protein S and factor VIII activity reference intervals revealed important differences, while antithrombin was similar to humans. Between sexes, reference intervals largely overlapped but were wider for free protein S and protein S activity. Factor VIII activity was 14% lower in group O baboons. This research has quantified some of the coagulation similarities and differences between Chacma baboons and humans.

Indexed as

AnticoagulantsFactor VIIIAnimalsBlood CoagulationBlood Coagulation TestsFemaleHumansMalePapioProtein CProtein SAnticoagulantsFactor VIIIProtein CProtein S)Chacma baboon (Papio ursinusFactor VIII activityKineticsNatural anticoagulantsReference intervalsThrombin generation

Identifiers

PMID40289133

DOI10.1038/s41598-025-94503-2

PMCPMC12034754

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.