Evidence map›Paper›PMID 40289059›Full record

ArticleDiscover oncology2025

Laparoscopic curative resection following perioperative chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel and its influence on Claudin18.2 expression in advanced gastric or gastroesophageal junction adenocarcinoma: a two-case report.

Tohru Takahashi, Takahiro Ishii, Taku Maejima, Eriko Aimono, Dai Miyazaki, Susumu Fukahori, Taichi Kimura, Mitsuru Yanai, Yusuke Ono, Masahiro Hagiwara and 1 more

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In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tohru TakahashiDepartment of General Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan. tohashi.75@gmail.com.ORCID http://orcid.org/0000-0002-1130-0549
Takahiro IshiiDepartment of Gastroenterology, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.ORCID http://orcid.org/0000-0002-9136-1818
Taku MaejimaDepartment of General Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Eriko AimonoDepartment of Pathology, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Dai MiyazakiDepartment of General Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Susumu FukahoriDepartment of General Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Taichi KimuraDepartment of Pathology, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Mitsuru YanaiDepartment of Pathology, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Yusuke OnoInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Masahiro HagiwaraDepartment of General Surgery, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.
Yusuke MizukamiInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, 3-1, North 33 East 14, East District, Sapporo, Hokkaido, 065-0033, Japan.ORCID http://orcid.org/0000-0002-1068-7024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel has improved survival in patients with locally advanced resectable gastric or gastroesophageal junction adenocarcinomas in Europe.

methodsWe report two cases of laparoscopic curative resection with perioperative docetaxel-based chemotherapy for advanced gastroesophageal junction or gastric adenocarcinoma and investigated variations in Claudin18.2 expressions associated with chemotherapy.

resultsPreoperative four-cycle docetaxel-based chemotherapy enabled laparoscopic total gastrectomy with distal esophagectomy via trans-hiatal approach or laparoscopic distal gastrectomy with extensive lymph node dissection. Postoperative left inferior pulmonary arterial thrombosis and chylous ascites recovered with pharmacotherapy and lipiodol lymphatic embolization. Despite discontinuing postoperative one-cycle chemotherapy, no recurrence was observed for over 1.5 and 1 year. Immunohistochemical staining showed increased Claudin18.2 expression in undifferentiated adenocarcinomas in the resected specimens than in pre-chemotherapeutic biopsies.

conclusionPerioperative docetaxel-based chemotherapy was effective for Japanese patients with gastroesophageal junction and gastric adenocarcinoma, suggesting a combination treatment with anti-Claudin18.2 antibody as neoadjuvant or first-line chemotherapy.

Indexed as

Claudin18.2FLOTGastroesophageal junction adenocarcinomaLaparoscopic curative resectionPerioperative chemotherapy

Identifiers

PMID40289059
PMCPMC12034610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.