ReviewChembiochem : a European journal of chemical biology2025
Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media.
Review in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Peptides as programmable molecular scaffolds: from chemical synthesis and engineering to translational medicine.RSC chemical biology · 2026Review
- Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026Review
- Nanoassembly-enabled aqueous solid-phase peptide synthesis (ASPPS): a practical DMF-free approach based on the Fmoc strategy.RSC advances · 2026Article
- Expanding amide bond formation with CaLB-BOP: from sterically hindered substrates to aqueous and micellar media.RSC advances · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Peptides are being increasingly explored for drug development as well as other applications, ranging from research tools to food additives. This growing interest in peptides has led to the need to develop new sustainable synthetic approaches for this class of molecules. The present review article focuses on the synthesis of peptides in aqueous media to drastically reduce organic solvent use and its consequent environmental impact. After some pioneering investigations about solid-phase peptide synthesis in water, the field is experiencing a renaissance also for the synthesis in solution spurred by increasing applications enabled by micellar catalysis. In this contribution, the challenges and opportunities offered by using aqueous and micellar media in the chemical synthesis of peptides are critically discussed.
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Registered trials
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