Evidence map›Paper›PMID 40288988›Full record

ReviewSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2025

[Research progress on the manufacturing technology of hollow microneedles].

Shengshuo Zhou, Huajian Zhou, Xiaoyu Du, Ziye Yu, Tongle Xu, Shun Zhao, Peiqiang Su, Leian Zhang, Guangyang Fu, Xuelei Liu

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shengshuo ZhouSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Huajian ZhouSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Xiaoyu DuSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Ziye YuSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Tongle XuSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Shun ZhaoSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Peiqiang SuShandong Huiyu Auto Parts Co., Ltd., Binzhou, Shandong 251702, P. R. China.
Leian ZhangSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Guangyang FuSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Xuelei LiuSchool of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug administration via hollow microneedles (HMN) have the advantages of painlessness, avoidance of first-pass effect, capability of sustained infusion, and no need for professional personnel operation. In addition, HMN can also be applied in the fields of body fluid extraction and biosensors, showing broad application prospects. However, traditional manufacturing technologies cannot meet the demand for low-cost mass production of HMN, limiting its widespread application. This paper reviews the main manufacturing technologies used for HMN in recent years, which include photolithography and etching, laser etching, sputtering and electroplating, micro-molding, three-dimensional (3D) printing and drawing lithography. It further analyzes the characteristics and limitations of existing manufacturing technologies and points out that the combination of various manufacturing technologies can improve production efficiency to a certain extent. In addition, this paper looks forward to the future trends of HMN manufacturing technology and proposes possible directions for its development. In conclusion, it is expected that this review can provide new ideas and references for follow-up research.

Indexed as

Drug Delivery SystemsMicroinjectionsNeedlesEquipment DesignHumansPrinting, Three-DimensionalHollow microneedleHollow microneedle materialManufacturing technologyMicroneedleProcess route

Identifiers

PMID40288988
PMCPMC12035629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.