Evidence map›Paper›PMID 40288969›Full record

ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2025

[Quantitative analysis of transcranial temporal interference stimulation in rodents: A simulation study on electrode configurations].

Xiaoxi Liu, Hongli Yu, Fushuai Gou, Boai Du, Pengyi Lu, Chunfang Wang

Abstract readEnglish Abstract
In one paragraph

Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Electric-field modeling, simulation, and experimental analysis of multi-target temporal interference transcranial alternating current stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  2. [Development and electrophysiological validation of a temporal interference transcranial magnetic stimulation system for mice].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoxi LiuSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Hongli YuSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Fushuai GouSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Boai DuSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Pengyi LuSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
Chunfang WangRehabilitation Medical Department, Tianjin Union Medical Centre, Tianjin 300121, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial temporal interference stimulation (tTIS) is a novel non-invasive transcranial electrical stimulation technique that achieves deep brain stimulation through multiple electrodes applying electric fields of different frequencies. Current studies on the mechanism of tTIS effects are primarily based on rodents, but experimental outcomes are often significantly influenced by electrode configurations. To enhance the performance of tTIS within the limited cranial space of rodents, we proposed various electrode configurations for tTIS and conducted finite element simulations using a realistic mouse model. Results demonstrated that ventral-dorsal, four-channel bipolar, and two-channel configurations performed best in terms of focality, diffusion of activated brain regions, and scalp impact, respectively. Compared to traditional transcranial direct current stimulation (tDCS), these configurations improved by 94.83%, 50.59%, and 3 514.58% in the respective evaluation metrics. This study provides a reference for selecting electrode configurations in future tTIS research on rodents.

Indexed as

BrainTranscranial Direct Current StimulationAnimalsComputer SimulationElectrodesFinite Element AnalysisMiceElectrode configurationTemporal interferenceTranscranial electrical stimulation

Identifiers

PMID40288969
PMCPMC12035621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.