ArticlePain2025
A multivariate statistical index, the fibromyalgia analog model, identifies Dahl S rats as a model of fibromyalgia with improved face validity.
Article in Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
abstractFibromyalgia syndrome (FMS) is clinically diagnosed using a widespread pain index and symptom severity scores. Despite this, multivariate statistical models using clinical data consistently suggest the presence of single overarching factor that can capture much of the variation across a spectrum of biomarkers for FMS, potentially aiding diagnosis. We hypothesized that a comparable single index could be developed for preclinical FMS rat models to quantitatively compare and rigorously test new candidates for improved translational potential and therapeutic screening. We used male and female reserpine-treated Sprague Dawley (SD) rats to produce the fibromyalgia analog model (FAM) index, a tool to systematically determine the robustness of potential models of FMS. Features associated with FMS were assessed by behavior tests, including widespread nociceptive sensitivity evaluated on the hind paws ("paw") and gastrocnemius muscles ("mus") using a Randall-Selitto device, and face ("VF") using von Frey filaments; depression (by the forced swim test [FST]); anxiety (using the Elevated Zero Maze [EZM]); and fatigue (using a Home Cage Monitoring system [HCM]). A multivariate statistical analysis was used to determine the FAM index and document internal and external model validity. The index equation was calculated to be F = 0.410 × rzpaw + 0.618 × rzmus + 0.429 × rzVF + 0.455 × zFST + 0.183 × RZ EZM + 0.160 × rzHCM , where each z is a standardized score. Our data showed the ability of the FAM index to differentiate saline-treated SD rats as a control, "normal" group, vs either acidic saline-injected SD or Dahl S rats as models displaying fibromyalgia-like behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.