SynthesisInternational wound journal2025
The Role of Infrasound and Audible Acoustic Sound in Modulating Wound Healing: A Systematic Review.
Synthesis in International wound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Toward a role for the acoustic field in cells interaction.Frontiers in systems neuroscience · 2025Article
- Infrasound in Biology and Medicine: Insights into Mechanisms, Health Outcomes and Research Perspectives - A Narrative Review.Noise & healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review evaluates the therapeutic effects of infrasound (1-20 Hz) and low-frequency audible sound (20 Hz-20 kHz) on wound healing, with a focus on cell migration, tissue regeneration, and bone repair. A comprehensive literature search across PubMed, Scopus, and Google Scholar was conducted to synthesise current data on these acoustic frequencies' impact on cellular functions. Key findings indicate that infrasound enhances bone growth and osteogenic differentiation of bone marrow stem cells, significantly accelerating fracture healing by increasing bone mineral density. Low-frequency sound at 100 Hz promotes fibroblast migration and alters cell morphology through actin restructuring, with effects varying by horizontal versus vertical vibrations. Additionally, frequencies of 10 and 20 kHz stimulate epidermal wound healing in mice by activating keratinocyte functions. These results highlight the potential of specific acoustic frequencies as non-invasive, cost-effective wound treatment options, particularly for bone regeneration and chronic wounds. Further research is recommended to refine acoustic parameters and validate clinical applications to establish therapeutic protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.