Evidence map›Paper›PMID 40288604›Full record

ReviewNeuropharmacology2025

Structural insights into the function, dysfunction and modulation of Kv3 channels.

Manuel Covarrubias, Qiansheng Liang, Linh Nguyen-Phuong, Kyle J Kennedy, Tyler D Alexander, Andrew Sam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. KFrontiers in pharmacology · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuel CovarrubiasDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA. Electronic address: Manuel.Covarrubias@jefferson.edu.
Qiansheng LiangDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA.
Linh Nguyen-PhuongDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA.
Kyle J KennedyDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA.
Tyler D AlexanderDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA.
Andrew SamDepartment of Neuroscience, Sidney Kimmel Medical College of Thomas Jefferson University, Bluemle Life Science Building, 233 South 10th Street, Room 231, Philadelphia, PA, 19107, USA; Vickie and Jack Farber Institute for Neuroscience, USA; Jefferson Synaptic Biology Center, USA.

Funding

Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic painR01NS110385 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Matthew B Dalva · 2018 to 2026
$4.4M
Targeting visceral pain through intestinal neuropod cell GUCY2C signalingR01DK138834 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Scott A. Waldman · 2023 to 2026
$3.4M
Neuromodulation of Kv3.4 channels in nociceptorsR21NS079855 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI COVARRUBIAS, MANUEL L · 2013 to 2014
$441k
NIDDK NIH HHS R01 DK138834NINDS NIH HHS R01 NS110385NINDS NIH HHS R21 NS079855
6 · The paper itself

Abstract

The third subfamily of voltage-gated K

Indexed as

Shaw Potassium ChannelsAnimalsHumansIon Channel GatingShaw Potassium ChannelsCryo-EMKv channelKv channel gatingKv channel modulatorsPain modulation

Identifiers

PMID40288604
PMCPMC12184066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.