Evidence map›Paper›PMID 40288581›Full record

Trial reportThe American journal of clinical nutrition2025

Resistance training increases myofibrillar protein synthesis in middle-to-older aged adults consuming a typical diet with no influence of protein source: a randomized controlled trial.

Marie Korzepa, Jonathan I Quinlan, Ryan N Marshall, Lucy M Rogers, Archie E Belfield, Yasir S Elhassan, Alex Lawson, Chloe Ayre, Joan M Senden, Joy Pb Goessens and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05574205 (The Importance of Dietary Protein Quality for Skeletal Muscle Anabolism in Older Adults), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05574205 nacompletednot on this map

The Importance of Dietary Protein Quality for Skeletal Muscle Anabolism in Older Adults

TypeinterventionalSponsorUniversity of BirminghamRan2021 to 2024Enrolled30ConditionsSarcopenia, Dietary Protein, Resistance ExerciseArmsResistance Exercise, Protein supplementation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marie KorzepaSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Jonathan I QuinlanSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, United Kingdom.
Ryan N MarshallSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Lucy M RogersSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Archie E BelfieldSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Yasir S ElhassanIntsitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
Alex LawsonBiochemistry Department, Heartlands Hospital, Birmingham, United Kingdom.
Chloe AyreBiochemistry Department, Heartlands Hospital, Birmingham, United Kingdom.
Joan M SendenDepartment of Human Biology, NUTRIM, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Joy Pb GoessensDepartment of Human Biology, NUTRIM, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Elisa I GloverSpecialised Nutrition Department, Volac Whey Nutrition Limited (Arla Food Ingredients Group), Royston, Hertfordshire, United Kingdom.
Gareth A WallisSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Luc Jc van LoonDepartment of Human Biology, NUTRIM, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Leigh BreenSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, United Kingdom. Electronic address: L.Breen@bham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe primary protein source of a diet may impact skeletal muscle maintenance with advancing age. The impact of the animal and plant protein contents of a typical protein-containing diet on muscle anabolism in middle-to-older aged adults is unknown.

objectivesTo determine muscle adaptive remodeling response to a 10-d dietary intervention containing divergent protein sources, with and without resistance exercise training (RET) in middle-to-older aged adults.

methodsIn a single-blind randomized controlled trial, 27 50- to 70-y-old participants consumed 1.0 g·kg BM

resultsDaily iMyoPS rates were significantly greater (P < 0.001) in the trained leg compared with the untrained leg for AW-D (1.44 ± 0.26 vs. 1.29 ± 0.27 %⋅d

conclusionsThe 10-d provision of 1.0g·kg BM CLINICAL TRIAL REGISTRY NUMBER: ClinicalTrials.gov NCT05574205 (https://clinicaltrials.gov/study/NCT05574205).

Indexed as

DietDietary ProteinsMuscle ProteinsMuscle, SkeletalMyofibrilsResistance TrainingAgedBody CompositionDietary SupplementsFemaleHumansMaleMiddle AgedSingle-Blind MethodWhey ProteinsDietary ProteinsMuscle ProteinsWhey Proteinsanimal proteinhuman physiologymuscle anabolismplant proteinresistance exercisesarcopenia

Identifiers

PMID40288581
PMCPMC12308137

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.