Evidence map›Paper›PMID 40287882›Full record

Trial reportLasers in medical science2025

A randomised comparative study of 1064 nm Nd:YAG laser and Urea occlusion therapy with topical miconazole for the treatment of onychomycosis.

Qing Cai, Li Meng, Xiaoping Liu, Zhiqin Gao, Hongjin Ren, Jingwen Tan, Lianjuan Yang

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qing CaiDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Li MengDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaoping LiuDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhiqin GaoDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Hongjin RenDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Jingwen TanDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Lianjuan YangDepartment of Dermatological Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. lianjuanyang@163.com.

Funding

Shanghai Hospital Development Center SHDC12019X37 and SHDC12017X25Shanghai Municipal Health Commission 202140336
6 · The paper itself

Abstract

Onychomycosis is a chronic fungal infectious disease and its treatment remains quite challenging at present. We aimed to evaluate the clinical efficacy of 1064 nm Nd:YAG laser in the treatment of onychomycosis. In this study, patients were randomly divided into three groups: laser (L), urea occlusion (UO), laser combined with urea occlusion (L + UO). Group L was treated with 1064 nm Nd:YAG laser. Group UO was treated with urea encapsulation. Group L + UO was treated with urea encapsulation followed by laser. All patients received Miconazole nitrate cream twice a day. Follow-up was conducted at 12 and 24 weeks. The Scoring Clinical Index for Onychomycosis (SCIO) and mycological examination were conducted. The clinical efficacy was evaluated based on the SCIO scores and the "temporary clear nail increase rate". A total of 59 patients with 110 affected nails were initially enrolled. Two patients (5 nails) were lost to follow-up, leaving 57 patients and 105 nails that had completed follow-up. At 24 weeks, in Group L, Group UO, and Group L + UO, the SCIO response rates were 42.86%, 66.67%, and 61.11%, respectively, the "temporary clear nail increase rates" were 19.05%, 16.67%, and 47.22%, respectively, and the mycological cure rates were 26.52%, 53.33%, and 56.52%, respectively. The "temporary clear nail increase rate" between Group L and Group L + UO, and the average SCIO before and after treatment in three groups was statistically significant. In conclusion, the combination of 1064 nm Nd:YAG laser and UO is an effective treatment for onychomycosis, which is of great significance for improving the therapeutic efficacy of onychomycosis.

Indexed as

Antifungal AgentsLasers, Solid-StateLow-Level Light TherapyMiconazoleOnychomycosisUreaAdministration, TopicalAdultAgedFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultAntifungal AgentsMiconazoleUreaComparative studyLaserOnychomycosisUrea occlusion

Identifiers

PMID40287882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.