Evidence map›Paper›PMID 40287877›Full record

ArticleNeuromolecular medicine2025

Gastrodin Protects Neuronal Cells Against Oxidative Stress Through miRNA-125b-5p/Mamdc2 Axis.

Lei Hu, Chao Lin, Renfu Li, Shouying Xu, Qiang Xu, Zihao An, Chao Tang

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lei Hu *National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Chao Lin *Department of Neurosurgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Renfu LiDepartment of Pediatric Surgery, Xiehe Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China.
Shouying XuDepartment of Pediatric Surgery, Xiehe Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China.
Qiang XuDepartment of Pediatric Surgery, Xiehe Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China.
Zihao AnNational Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Chao TangNational Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China. chtang@zju.edu.cn.

Funding

National Natural Science Foundation of China 82471715
6 · The paper itself

Abstract

Deregulated reactive oxygen species (ROS) levels trigger oxidative stress (OS) injury that is closely associated with the pathophysiology of various neurological disorders. Therefore, therapeutic efforts at oxidative events in the pathway of neuronal degeneration would be promisingly helpful for intervention and treatment of related diseases. Here, we report that gastrodin, the main bioactive constituent of Rhizoma Gastrodiae, protects the mouse hippocampal HT22 cells from OS caused by hydrogen peroxide (H

Indexed as

Benzyl AlcoholsGlucosidesMicroRNAsNerve Tissue ProteinsNeuronsNeuroprotective AgentsOxidative StressAnimalsCell LineCell SurvivalGlutathioneHippocampusHydrogen PeroxideMalondialdehydeMiceReactive Oxygen SpeciesBenzyl AlcoholsgastrodinGlucosidesGlutathioneHydrogen PeroxideMalondialdehydeMicroRNAsMirn125 microRNA, mouseNerve Tissue ProteinsNeuroprotective AgentsReactive Oxygen SpeciesGastrodinMamdc2miRNA-125b-5pNeuronal cellsOxidative stress

Identifiers

PMID40287877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.