Evidence map›Paper›PMID 40287871›Full record

ArticleEuropean radiology2025

Fibroblast activation imaging in rheumatoid arthritis: evaluating disease activity and treatment response using [

Xingyu Mu, Fangyue Zhang, Meng Li, Lu Lu, Biyun Mo, Baozhen Li, Min Yang, Wei Fu

Abstract read
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In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingyu Mu *Department of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Fangyue Zhang *Department of Rheumatology and Immunology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Meng LiDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Lu LuDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Biyun MoDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Baozhen LiDepartment of Rheumatology and Immunology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Min YangDepartment of Rheumatology and Immunology, Affiliated Hospital of Guilin Medical University, Guilin, China. liangyangmin@163.com.
Wei FuDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China. fuwei19700513@163.com.ORCID http://orcid.org/0009-0000-5173-6331

Funding

National Natural Science Foundation of China 82360360National Natural Science Foundation of China 82402332National Natural Science Foundation of China 82460356
6 · The paper itself

Abstract

objectivesTo evaluate the utility of fibroblast activation protein (FAP) imaging using [¹⁸F]FAPI PET/CT for assessing disease activity and monitoring treatment response in rheumatoid arthritis (RA). MATERIALS AND

methodsA prospective, single-center study was conducted with 42 RA patients and 8 healthy controls. Participants underwent clinical assessment and [¹⁸F]FAPI PET/CT imaging. Semiquantitative parameters, including standardized uptake value maximum (SUV

results[¹⁸F]FAPI PET/CT identified 201 RA-affected joints with significantly higher SUV

conclusion[¹⁸F]FAPI PET/CT is a promising tool for non-invasive assessment of RA disease activity. It provides quantitative insights into fibroblast activation, offering potential to enhance disease management and therapeutic planning. KEY POINTS: Question What is the potential of fibroblast activation imaging using [

Indexed as

Arthritis, RheumatoidFibroblastsGelatinasesMembrane ProteinsPositron Emission Tomography Computed TomographySerine EndopeptidasesAdultAgedEndopeptidasesFemaleFibroblast Activation Protein AlphaFluorine RadioisotopesHumansMaleMiddle AgedProspective StudiesEndopeptidasesFibroblast Activation Protein AlphaFluorine RadioisotopesGelatinasesMembrane ProteinsRadiopharmaceuticalsSerine Endopeptidases[18F]FAPI PET/CTDisease activity assessmentFibroblast activationRheumatoid arthritisTreatment monitoring

Identifiers

PMID40287871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.