SynthesisBMC pediatrics2025
Epidemiology and management of massive, sub-massive, and non-massive pediatric pulmonary embolism: a systematic reviews.
Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the current evidence on the diagnosis, management, and outcomes of pediatric pulmonary embolism (PE) across varying severity classifications, including massive, submassive, and non-massive presentations.
methodsA systematic review was conducted following PRISMA guidelines. Searches were performed in PubMed, Scopus, Web of Science, and Cochrane databases up to February 17, 2024. Eligible studies included pediatric and adolescent patients (≤ 21 years) with confirmed PE diagnoses. Risk of bias was assessed using the NIH tool.
resultsSix studies involving 258 pediatric patients with massive, submassive, or non-massive PE were included. Most patients were adolescents, with a mean age of 14.1 years and a predominance of females (62-66%). Risk factors included obesity, oral contraceptive use, thrombophilia, and autoimmune conditions. Computed tomography pulmonary angiography (CTPA) was the most frequently used diagnostic modality, showing varied lobar, segmental, and subsegmental involvement. Management strategies ranged from anticoagulation to catheter-directed thrombolysis and surgical thrombectomy. Outcomes varied by severity, with massive PE cases showing higher mortality and complications compared to submassive and non-massive cases.
conclusionPediatric PE requires tailored risk stratification and management strategies to optimize outcomes. Delays in diagnosis and severe disease presentations contribute to higher morbidity and mortality. Future research should focus on standardized severity classifications, novel diagnostic modalities, and comparative assessments of therapeutic interventions to enhance outcomes in this population.
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