Evidence map›Paper›PMID 40287617›Full record

Observational studyBMC pregnancy and childbirth2025

Impact of maternal anemia during pregnancy on neonatal metabolic profiles: evidence from the Beijing Birth Cohort Study.

Shunan Wang, Wei Zheng, Jinqi Zhao, Lulu Li, Yue Tang, Lifei Gong, Lijin Gu, Guanghui Li, Yuanyuan Kong

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shunan WangDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Wei ZhengDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Jinqi ZhaoDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Lulu LiDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Yue TangDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Lifei GongDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Lijin GuDepartment of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China.
Guanghui Li *Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China. liguanghui@ccmu.edu.cn.
Yuanyuan Kong *Department of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Healthcare Hospital, Beijing, China. kongyuanyuan1971@mail.ccmu.edu.cn.

Funding

National Key Research and Development Program of China 2016YFC1000304
6 · The paper itself

Abstract

backgroundAnemia during pregnancy is associated with various adverse neonatal outcomes. However, the association between maternal anemia during pregnancy and newborn metabolic profiles remains unclear. This study aimed to investigate whether anemia during pregnancy is associated with alterations in neonatal metabolic profiles.

methodsThis prospective observational cohort study included 12,116 pregnant women, with or without gestational anemia, recruited through the Beijing Birth Cohort Study (ChiCTR2200058395), along with their neonates born between July 2021 and October 2022 in Beijing, China.

resultsAmong the 12,116 participants, 576 pregnant women were diagnosed with anemia (Anemia group), while 11,540 did not have anemia (Control group). The rates of metabolic profile abnormalities were significantly higher in the Anemia group compared to the Control group (P < 0.05): 20.83% vs. 16.1% for the overall metabolic profile, 11.9% vs. 9.25% for amino acid profiles, and 11.11% vs. 8.04% for acylcarnitine profiles. Individual metabolic indicators showed significant differences: alanine and arginine levels significantly decreased, while tyrosine levels significantly increased in the Anemia group. Notably, most acylcarnitines indicators (C0, C2, C4DC + C5-OH, C5DC + C6-OH, C6, C6DC, C10, C10:1, C12, C12:1, C14, C14:1, C14:2, C16, C16:1, C16:1-OH, C18, and C18:1) were significantly reduced in the Anemia group, except for C5, which was elevated. Pathway analysis revealed that these alterations were associated with beta-oxidation of very long-chain fatty acids, oxidation of branched-chain fatty acids, mitochondrial beta-oxidation of long-chain saturated fatty acids, and fatty acid metabolism. All of these pathways were related to fatty acid oxidation. Sensitive analyses in normal birth weight (NBW) and term infants (TI) confirmed these findings and demonstrated their robustness. In addition, in NBW infants and TIs, citrulline and arginine were significantly decreased, which were associated with aspartate metabolism and the urea cycle.

conclusionsMaternal anemia during pregnancy is significantly associated with alterations in neonatal metabolic profiles, particularly in fatty acid beta-oxidation and related pathways. These findings highlight the potential metabolic consequences of gestational anemia and provide insights into its role in adverse neonatal outcomes and abnormal newborn screening results.

Indexed as

AnemiaMetabolomePregnancy Complications, HematologicAdultAmino AcidsBeijingBirth CohortCarnitineChinaFemaleHumansInfant, NewbornPregnancyProspective StudiesacylcarnitineAmino AcidsCarnitineAcylcarnitinesAmino acidsAnemia during pregnancyFatty acid oxidationMetabolismNewborn metabolic profiles

Identifiers

PMID40287617
PMCPMC12032785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.