ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Should infranotch T4b oral cavity cancer be downstage to T4a category?
Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The combined compartmental maxillary resection: technique codification and preliminary multicenter series analysis.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis comment aims to discuss the reliability of a radical resection of T4b oral squamous cell carcinomas with masticatory space involvement as well as analyze data in the literature on the oncologic outcomes compared to T4a.
methodsClinical review of the scientific literature with focus on oral squamous cell carcinomas with masticatory space involvement.
resultsThe clinical review comprised 10 studies. The masticatory space is subdivided into infra- and supra-notch spaces according to the plane passing through the mandibular notch. En-bloc resection with compartmental approach demonstrated similar outcomes for infra-notch T4b oral cancers and T4a category.
conclusionEn-bloc compartmental resection of the masticatory space provides the best chances of margins control. Surgery should be considered the first line treatment option for this "borderline operable" category of cancers. Comparable survival outcomes between T4a and infra-notch T4b pushed several authors to suggest the downstaging the masticatory space involvement in oral cancer to T4a category.
Indexed as
Identifiers
40287585What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.