ArticleCommunications biology2025
Multimodal identification of the mouse brain using simultaneous Ca
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Simultaneous single-cell calcium imaging of neuronal population activity and brain-wide BOLD fMRI.Nature methods · 2026Article
- Channel Capacity for Time-Resolved Effective Connectivity in Functional Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States.Theranostics · 2026Article
- Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026Article
- Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice.bioRxiv : the preprint server for biology · 2025Article
- Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Molecular psychiatry · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Individual differences in neuroimaging are of interest to clinical and cognitive neuroscientists based on their potential for guiding the personalized treatment of various heterogeneous neurological conditions and diseases. Despite many advantages, the prevailing modality in this field-blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI)-suffers from low spatiotemporal resolution and specificity as well as a propensity for noise and spurious signal corruption. To better understand individual differences in BOLD-fMRI data, we can use animal models where fMRI, alongside complementary but more invasive contrasts, can be accessed. Here, we apply simultaneous wide-field fluorescence calcium imaging and BOLD-fMRI in mice to interrogate individual differences using a connectome-based identification framework adopted from the human fMRI literature. This approach yields high spatiotemporal resolution cell-type specific signals (here, from glia, excitatory, as well as inhibitory interneurons) from the whole cortex. We found mouse multimodal connectome-based identification to be successful and explored various features of these data.
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