Evidence map›Paper›PMID 40287517›Full record

ArticleLung2025

Genome-Wide Differential Airway Gene Expression Analysis Identifies Genes Associated with COPD Comorbidities.

Alen Faiz, Else A M D Ter Haar, Jorine E Hartman, Corry-Anke Brandsma, Wim Timens, Janette K Burgess, David F Choy, Michele A Grimbaldeston, Lowie E G W Vanfleteren, Dirk-Jan Slebos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alen FaizRespiratory Bioinformatics and Molecular Biology Group, University of Technology Sydney, Sydney, Australia.
Else A M D Ter HaarDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jorine E HartmanDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Corry-Anke BrandsmaGRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wim TimensGRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Janette K BurgessGRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
David F ChoyGenentech Inc., South San Francisco, CA, USA.
Michele A GrimbaldestonGenentech Inc., South San Francisco, CA, USA.
Lowie E G W VanfleterenCOPD Center, Sahlgrenska University Hospital and Institute of Medicine, Gothenburg University, Gothenburg, Sweden.
Dirk-Jan SlebosDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Maarten van den BergeDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Simon D PouwelsDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. s.d.pouwels@umcg.nl.ORCID https://orcid.org/0000-0001-7345-8061

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek VENI no. 09150162010003
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is often associated with the co-occurrence of extra-pulmonary diseases, yet the underlying pathophysiology of comorbidities is poorly understood. In COPD patients, the bronchial epithelium often displays cellular damage and is chronically inflamed. The current study aimed to identify differentially expressed genes in bronchial epithelium of COPD patients with and without comorbidities. To this end, a genome-wide differential gene expression analysis was performed on bronchial epithelial samples of 123 severe COPD patients with and without the following comorbidities: anxiety, atherosclerosis, depression, hypercholesterolemia, hypertension, muscle wasting, osteoporosis, and low BMI. COPD patients with osteoporosis displayed higher expression of COL6A3 and lower expression of PHEX. Furthermore, COPD patients with hypercholesterolemia displayed a distinct bronchial epithelial gene expression profile, with 162 differentially expressed genes. No differentially expressed genes were identified for the other comorbidities. This study identified differentially expressed bronchial epithelial genes associated with osteoporosis and hypercholesterolemia in COPD patients.

Indexed as

BronchiPulmonary Disease, Chronic ObstructiveRespiratory MucosaTranscriptomeAgedComorbidityFemaleGene Expression ProfilingGenome-Wide Association StudyHumansHypercholesterolemiaMaleMiddle AgedOsteoporosisComorbiditiesCOPDGWASHypercholesterolemiaNotchOsteoporosis

Identifiers

PMID40287517
PMCPMC12033178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.